Neither molecular biology nor the sane part of physics has any of em.

Btw, it is heuristic - if there are numbers involved then it is human made. Reality as it is has no such notion. Biology does not count.

Numbers require an observer, which is a by-product of the processes in vastly complex brain structures of the cortex, and cannot be the basis of anything in the underlying universe.

Any good (which means Eastern) philosophy arrived at these simple conclusions millennia ago.