Yes. It is rude to ask a woman if her breasts are real. It is rude to ask a woman if you can touch her breasts. It is rude to tell a woman her breasts look nice. All of these things are rude. Unless the woman is showing you her naked breasts and asking what you think, commenting on her breasts is rude.
Consider this: Is it rude if I comment on the size of your penis? Would you find it rude, even if I complemented how big it looks in your pants, so big that I'm wondering whether it's real, whether you're packing? Would you find that rude?