Donald Trump lashed out Tuesday morning against House Speaker Paul D. Ryan (R-Wis.) and other Republicans who have distanced themselves from him, as the extraordinary turbulence in the Republican Party intensified four weeks from Election Day.

In tweets, Trump called Ryan “weak and ineffective,” accused him of providing “zero support,” said Democrats are more loyal than Republicans and declared that “the shackles have been taken off” him, freeing him to “fight for America the way I want to.”

Ryan said Monday that he would no longer defend or campaign with Trump. The Republican presidential nominee lost substantial support among GOP elected officials after The Washington Post reported on a 2005 video in which Trump can be heard making vulgar comments about physically forcing himself on women.

“Paul Ryan is focusing the next month on defeating Democrats, and all Republicans running for office should probably do the same,” Ryan spokesman Brendan Buck said in a statement responding to Trump's tweets.