UniProtKB - Q96AC6 (KIFC2_HUMAN)
UniProt
Q96AC6 - KIFC2_HUMAN
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Protein
Kinesin-like protein KIFC2
Gene
KIFC2
Organism
Homo sapiens (Human)
Sequence features
Status
Functioni
May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity).By similarity
Regions
Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
---|---|---|---|---|---|---|
Nucleotide bindingi | 484 – 491 | 8 | ATPPROSITE-ProRule annotation |
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- microtubule motor activity Source: GO_Central
GO - Biological processi
- microtubule-based movement Source: GO_Central
Keywords - Molecular functioni
Motor proteinKeywords - Ligandi
ATP-binding, Nucleotide-bindingNames & Taxonomyi
Protein namesi | Recommended name: Kinesin-like protein KIFC2 |
Gene namesi | Name:KIFC2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi | UP000005640: Chromosome 8 Componenti |
Organism-specific databases
HGNCi | HGNC:29530. KIFC2. |
Subcellular locationi
- Cytoplasm › cytoskeleton Curated
GO - Cellular componenti
- cytoplasm Source: UniProtKB-KW
- kinesin complex Source: GO_Central
- microtubule Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Organism-specific databases
PharmGKBi | PA134874212. |
Polymorphism and mutation databases
BioMutai | KIFC2. |
DMDMi | 34098674. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
---|---|---|---|---|---|---|
Chaini | 1 – 838 | 838 | Kinesin-like protein KIFC2 | PRO_0000125429 | Add BLAST |
Proteomic databases
PaxDbi | Q96AC6. |
PRIDEi | Q96AC6. |
PTM databases
PhosphoSitei | Q96AC6. |
Expressioni
Gene expression databases
Bgeei | Q96AC6. |
CleanExi | HS_KIFC2. |
Genevisiblei | Q96AC6. HS. |
Organism-specific databases
HPAi | HPA029264. |
Interactioni
Protein-protein interaction databases
BioGridi | 124785. 4 interactions. |
IntActi | Q96AC6. 7 interactions. |
MINTi | MINT-7241349. |
STRINGi | 9606.ENSP00000301332. |
Structurei
3D structure databases
ProteinModelPortali | Q96AC6. |
SMRi | Q96AC6. Positions 407-743. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
---|---|---|---|---|---|---|
Domaini | 409 – 740 | 332 | Kinesin motorPROSITE-ProRule annotation | Add BLAST |
Coiled coil
Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
---|---|---|---|---|---|---|
Coiled coili | 186 – 351 | 166 | Sequence Analysis | Add BLAST |
Compositional bias
Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
---|---|---|---|---|---|---|
Compositional biasi | 181 – 332 | 152 | Gln-rich | Add BLAST | ||
Compositional biasi | 720 – 831 | 112 | Pro-rich | Add BLAST |
Sequence similaritiesi
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | COG5059. |
GeneTreei | ENSGT00550000074610. |
HOGENOMi | HOG000113226. |
HOVERGENi | HBG052258. |
InParanoidi | Q96AC6. |
KOi | K10406. |
OMAi | RELQQMH. |
OrthoDBi | EOG7ZKS9J. |
PhylomeDBi | Q96AC6. |
TreeFami | TF105238. |
Family and domain databases
Gene3Di | 3.40.850.10. 1 hit. |
InterProi | IPR027640. Kinesin-like_fam. IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. IPR027417. P-loop_NTPase. [Graphical view] |
PANTHERi | PTHR24115. PTHR24115. 1 hit. |
Pfami | PF00225. Kinesin. 1 hit. [Graphical view] |
PRINTSi | PR00380. KINESINHEAVY. |
SMARTi | SM00129. KISc. 1 hit. [Graphical view] |
SUPFAMi | SSF52540. SSF52540. 1 hit. |
PROSITEi | PS00411. KINESIN_MOTOR_1. 1 hit. PS50067. KINESIN_MOTOR_2. 1 hit. [Graphical view] |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96AC6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MYAFYSLLIY IFYSLFRRDG GAAAAAEPGD PAQRARKPRG RRRPDLPAPE
60 70 80 90 100
LWTELTGLAA SSEPEDGSEG AAEGRAAAVS LEEALLRLAE FLSVQLGAEE
110 120 130 140 150
SCGGPADLGQ SGEVPSLLTV TSQLLALLAW LRSPRGRQAL LQGTQPAPRV
160 170 180 190 200
RPPSPDGSTS QEESPSHFTA VPGEPLGDET QGQQPLQLEE DQRAWQRLEQ
210 220 230 240 250
LILGQLEELK QQLEQQEEEL GRLRLGVGAT DSEKRVQHLT LENEALKQSL
260 270 280 290 300
SLMRDLLLHW GPGPPIRAPQ EEAEALLELQ GRLQEAQDTT EALRAQLGVQ
310 320 330 340 350
EVQLQGLQGA LQQLQQETEQ NCRRELQQMH GQLAGLRARM ASLRQGCGDL
360 370 380 390 400
RGLVSTFTQS CQGSLSEARG QVSWALGALS SGGPGTQLPE GQQGPPAGCP
410 420 430 440 450
GRLPELKGNI RVLCRLRPGT SSSLVSVEPG PGGTVTTCYR GRHRRFRLDW
460 470 480 490 500
VFPPDASQEE VFRELEPAVL SCLRGYSVCI FTYGQTGTGK TYSMEGPPED
510 520 530 540 550
PGIVPRALQS LFREMGAGRQ HRVTLSMVEI YNEAVRDLLA PGPPERLAVR
560 570 580 590 600
QGPEGQGGIQ VAGLTHWDVP NLETLHQMLK LGRSNRATAA TAMNQRSSRS
610 620 630 640 650
HALVTLTLRA ASPPRAPGTA GTLHLVDLAG SERARKAGAA GPPRGDPDGA
660 670 680 690 700
RRLREAQTIN RSLLALGGVM AALRAHRPHV PFRDSQLTRL LQPALGPGTT
710 720 730 740 750
AVLLLQVGAG AGQVCACRSP PTRARPPAPL ARRSPRGRRI SGRQSAPSSS
760 770 780 790 800
PTEWVKWSWG QPGAAGSRAP PGRLLPSAPT LRSPGPPAPL RRPLAVLHAP
810 820 830
VPTTARARLS RPQRACPSSP GSRPCPWGLR PGLCWQRR
Natural variant
Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
---|---|---|---|---|---|---|
Natural varianti | 67 – 67 | 1 | G → E. Corresponds to variant rs35817880 [ dbSNP | Ensembl ]. | VAR_049684 | ||
Natural varianti | 166 – 166 | 1 | S → F. Corresponds to variant rs12675537 [ dbSNP | Ensembl ]. | VAR_049685 |
Alternative sequence
Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
---|---|---|---|---|---|---|
Alternative sequencei | 1 – 252 | 252 | Missing in isoform 2. 1 Publication | VSP_056102 | Add BLAST | |
Alternative sequencei | 523 – 551 | 29 | VTLSM…LAVRQ → RYHGRCLSPAESPEHPRPGL PPCRARSPL in isoform 2. 1 Publication | VSP_056103 | Add BLAST | |
Alternative sequencei | 552 – 838 | 287 | Missing in isoform 2. 1 Publication | VSP_056104 | Add BLAST |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055045 mRNA. Translation: BAB70844.1. AC084125 Genomic DNA. No translation available. CH471162 Genomic DNA. Translation: EAW82085.1. BC017311 mRNA. Translation: AAH17311.1. |
CCDSi | CCDS6427.1. [Q96AC6-1] |
RefSeqi | NP_665697.1. NM_145754.3. [Q96AC6-1] |
UniGenei | Hs.528713. |
Genome annotation databases
Ensembli | ENST00000301332; ENSP00000301332; ENSG00000167702. [Q96AC6-1] |
GeneIDi | 90990. |
KEGGi | hsa:90990. |
UCSCi | uc003zcz.3. human. [Q96AC6-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismCross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055045 mRNA. Translation: BAB70844.1. AC084125 Genomic DNA. No translation available. CH471162 Genomic DNA. Translation: EAW82085.1. BC017311 mRNA. Translation: AAH17311.1. |
CCDSi | CCDS6427.1. [Q96AC6-1] |
RefSeqi | NP_665697.1. NM_145754.3. [Q96AC6-1] |
UniGenei | Hs.528713. |
3D structure databases
ProteinModelPortali | Q96AC6. |
SMRi | Q96AC6. Positions 407-743. |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 124785. 4 interactions. |
IntActi | Q96AC6. 7 interactions. |
MINTi | MINT-7241349. |
STRINGi | 9606.ENSP00000301332. |
PTM databases
PhosphoSitei | Q96AC6. |
Polymorphism and mutation databases
BioMutai | KIFC2. |
DMDMi | 34098674. |
Proteomic databases
PaxDbi | Q96AC6. |
PRIDEi | Q96AC6. |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000301332; ENSP00000301332; ENSG00000167702. [Q96AC6-1] |
GeneIDi | 90990. |
KEGGi | hsa:90990. |
UCSCi | uc003zcz.3. human. [Q96AC6-1] |
Organism-specific databases
CTDi | 90990. |
GeneCardsi | GC08P144466. |
HGNCi | HGNC:29530. KIFC2. |
HPAi | HPA029264. |
neXtProti | NX_Q96AC6. |
PharmGKBi | PA134874212. |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | COG5059. |
GeneTreei | ENSGT00550000074610. |
HOGENOMi | HOG000113226. |
HOVERGENi | HBG052258. |
InParanoidi | Q96AC6. |
KOi | K10406. |
OMAi | RELQQMH. |
OrthoDBi | EOG7ZKS9J. |
PhylomeDBi | Q96AC6. |
TreeFami | TF105238. |
Miscellaneous databases
ChiTaRSi | KIFC2. human. |
GenomeRNAii | 90990. |
NextBioi | 77060. |
PROi | Q96AC6. |
Gene expression databases
Bgeei | Q96AC6. |
CleanExi | HS_KIFC2. |
Genevisiblei | Q96AC6. HS. |
Family and domain databases
Gene3Di | 3.40.850.10. 1 hit. |
InterProi | IPR027640. Kinesin-like_fam. IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. IPR027417. P-loop_NTPase. [Graphical view] |
PANTHERi | PTHR24115. PTHR24115. 1 hit. |
Pfami | PF00225. Kinesin. 1 hit. [Graphical view] |
PRINTSi | PR00380. KINESINHEAVY. |
SMARTi | SM00129. KISc. 1 hit. [Graphical view] |
SUPFAMi | SSF52540. SSF52540. 1 hit. |
PROSITEi | PS00411. KINESIN_MOTOR_1. 1 hit. PS50067. KINESIN_MOTOR_2. 1 hit. [Graphical view] |
ProtoNeti | Search... |
Publicationsi
- "Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).Tissue: Brain. - "DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. - Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. - "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).Tissue: Pancreas.
Entry informationi
Entry namei | KIFC2_HUMAN | ||||||||
Accessioni | Q96AC6Primary (citable) accession number: Q96AC6 Secondary accession number(s): E9PHB2, Q96NN6 | ||||||||
Entry historyi |
| ||||||||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Annotation program | Chordata Protein Annotation Program | ||||||||
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 8Human chromosome 8: entries, gene names and cross-references to MIM
- Human entries with polymorphisms or disease mutationsList of human entries with polymorphisms or disease mutations
- Human polymorphisms and disease mutationsIndex of human polymorphisms and disease mutations
- SIMILARITY commentsIndex of protein domains and families
External Data
Dasty 3Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry. |
90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |