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ELI5: Why are some medications race-based? (self.explainlikeimfive)

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[–]the_original_Retro 29ポイント30ポイント  (38子コメント)

There's sufficient genetic difference between various human races to create different reactions to certain drugs, or increase the possibility of certain reactions in certain races.

An example of one such difference is a genetic switch in some Asians that floors them completely when they have one drink because their metabolism very rapidly turns the alcohol they ingest into acetaldehyde, which is poisonous when in larger doses and gives them wicked hangovers.

Some drugs are metabolized or take effect in different ways as programmed by race-specific genetics, and that can lead to bad side-effects such as cancer or a drug that just doesn't work at all.

[–]lollersauce914 10ポイント11ポイント  (6子コメント)

Well, in addition to the genes that cause skin color, people of different races tend to share lots of other genes. For example, a particular form of heart failure is very prominent among blacks compared with whites (even when controlling for other factors). As such, a drug was approved to deal with this specific problem that tends to disproportionately effect black people.

Race based medicine is a controversial subset of personalized medicine. The whole idea of personalized medicine is tailoring treatments to your own personal body, genes, and conditions. Since racial groups have very similar genetics compared with people outside that group, race-based medicine can be a stepping stone towards personalized medicine.

[–]iamthelol1 -1ポイント0ポイント  (4子コメント)

If it's true fact, then why is it controversial? If it is indeed true, people just need to accept the small difference between different races.

[–]bulksalty -1ポイント0ポイント  (1子コメント)

Because the last time someone ascribed different characteristics to genetic differences, his nation killed 6 million people.

[–]iamthelol1 1ポイント2ポイント  (0子コメント)

But that wasn't true. No proof for it at all, and in fact, the Nazis were digging their own grave by imprisoning and executing millions of people who could be conscripted instead. There is sufficient evidence for differences in disease resistance, however.

[–]Luzer606 1ポイント2ポイント  (0子コメント)

I worked in Regulatory Operations at a large Pharmaceutical company processing and publishing the drug submissions to the FDA in the late 90s. All the drugs in development at the time that I worked on had the highest efficacy rates for whites and asians and the lowest efficacy for blacks and hispanics. For all of the drugs the dosage recommendations were based on the efficacy on whites and asians. The drugs would work for other races but at higher dosages than the prescribing guidelines.

[–]MrFrieds 3ポイント4ポイント  (0子コメント)

I wouldn't call Medication "Race Based". Much of the efficacy of medicine has to do with the condition you are being treated for. Certain subsets of the population are more likely than others to have certain diseases and genetic abnormalities which can make medicine either more effective or less effective. This provides the appearence of a "Race" or "Genetic" Based" distribution of medicine despite not being such.

[–]r3solv -2ポイント-1ポイント  (0子コメント)

Because in studies it was found that the drug affected the race differently, usually better than others. Especially for things like high blood pressure. It's much more technical, but even a .001% difference in DNA could make a drug 90% more effective, I suppose.

[–]Ilnor -1ポイント0ポイント  (0子コメント)

That's not how you ELI5, He's five. Explain it like he's 5

People are born different some groups of people have some things in common that we can give them medicine for, But it doesn't work so good for other people.

If you want one of those answers, Just google it