UniProtKB - P41958 (CED9_CAEEL)
UniProt
P41958 - CED9_CAEEL
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Protein
Apoptosis regulator ced-9
Gene
ced-9
Organism
Caenorhabditis elegans
Sequence features
Status
Functioni
Plays a major role in programmed cell death (PCD, apoptosis). Egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3.6 Publications
GO - Molecular functioni
- GTPase activator activity Source: WormBase
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- negative regulation of apoptotic process Source: WormBase
- negative regulation of programmed cell death Source: WormBase
- positive regulation of GTPase activity Source: GOC
- positive regulation of mitochondrial fusion Source: WormBase
Keywords - Biological processi
ApoptosisProtein family/group databases
TCDBi | 1.A.21.2.1. the bcl-2 (bcl-2) family. |
Names & Taxonomyi
Protein namesi | Recommended name: Apoptosis regulator ced-9Alternative name(s): Cell death protein 9 |
Gene namesi | Name:ced-9 ORF Names:T07C4.8 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi | UP000001940: Chromosome III Componenti |
Organism-specific databases
WormBasei | T07C4.8; CE25104; WBGene00000423; ced-9. |
Subcellular locationi
- Endomembrane system; Peripheral membrane protein
- Mitochondrion membrane; Peripheral membrane protein
Note: Intracellular membranes, mitochondrial, and perinuclear region.
GO - Cellular componenti
- endomembrane system Source: UniProtKB-SubCell
- membrane Source: WormBase
- mitochondrial outer membrane Source: WormBase
- mitochondrion Source: WormBase
- organelle membrane Source: WormBase
- perinuclear region of cytoplasm Source: WormBase
Keywords - Cellular componenti
Membrane, MitochondrionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
---|---|---|---|---|---|---|
Mutagenesisi | 149 – 149 | 1 | Y → N in N1653; lethal phenotype. 1 Publication | |||
Mutagenesisi | 169 – 169 | 1 | G → E in G169E; gain of function. 1 Publication |
PTM / Processingi
Molecule processing
Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
---|---|---|---|---|---|---|
Chaini | 1 – 280 | 280 | Apoptosis regulator ced-9 | PRO_0000143097 | Add BLAST |
Proteomic databases
PaxDbi | P41958. |
PRIDEi | P41958. |
Expressioni
Developmental stagei
Abundant expression is seen in embryos and adults.1 Publication
Interactioni
Subunit structurei
Interacts with ced-4 (PubMed:9027313). Interacts with egl-1 (PubMed:9604928, PubMed:12894216, PubMed:15383288). Interacts with dre-1; the interaction inhibits ced-9 activity, either directly or indirectly (PubMed:23431138).5 Publications
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
ced-3 | P42573 | 2 | EBI-494110,EBI-494247 | |
ced-4 | P30429 | 18 | EBI-494110,EBI-494118 | |
egl-1 | O61667 | 6 | EBI-494110,EBI-495949 |
Protein-protein interaction databases
BioGridi | 533094. 4 interactions. |
DIPi | DIP-250N. |
IntActi | P41958. 3 interactions. |
MINTi | MINT-1526902. |
STRINGi | 6239.T07C4.8. |
Structurei
Secondary structure
1
280
Legend: HelixTurnBeta strand
Show more detailsFeature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
---|---|---|---|---|---|---|
Helixi | 72 – 74 | 3 | Combined sources | |||
Helixi | 76 – 78 | 3 | Combined sources | |||
Helixi | 80 – 94 | 15 | Combined sources | |||
Helixi | 111 – 138 | 28 | Combined sources | |||
Beta strandi | 140 – 143 | 4 | Combined sources | |||
Helixi | 146 – 153 | 8 | Combined sources | |||
Turni | 154 – 157 | 4 | Combined sources | |||
Beta strandi | 161 – 163 | 3 | Combined sources | |||
Helixi | 168 – 185 | 18 | Combined sources | |||
Turni | 189 – 191 | 3 | Combined sources | |||
Helixi | 192 – 194 | 3 | Combined sources | |||
Helixi | 195 – 211 | 17 | Combined sources | |||
Helixi | 214 – 217 | 4 | Combined sources | |||
Helixi | 221 – 239 | 19 | Combined sources |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated |
| ||||||||||||||||||||||||
ProteinModelPortali | P41958. | ||||||||||||||||||||||||
SMRi | P41958. Positions 71-236. | ||||||||||||||||||||||||
ModBasei | Search... | ||||||||||||||||||||||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P41958. |
Family & Domainsi
Motif
Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
---|---|---|---|---|---|---|
Motifi | 80 – 99 | 20 | BH4 | Add BLAST | ||
Motifi | 160 – 179 | 20 | BH1 | Add BLAST | ||
Motifi | 213 – 229 | 17 | BH2 | Add BLAST |
Sequence similaritiesi
Belongs to the Bcl-2 family.Curated
Phylogenomic databases
eggNOGi | NOG326862. |
HOGENOMi | HOG000111534. |
InParanoidi | P41958. |
OMAi | YVEVVEC. |
OrthoDBi | EOG764748. |
PhylomeDBi | P41958. |
Family and domain databases
InterProi | IPR002475. Bcl2-like. IPR020717. Bcl2_BH1_motif_CS. IPR003093. Bcl2_BH4. IPR026298. Blc2_fam. [Graphical view] |
PANTHERi | PTHR11256. PTHR11256. 1 hit. |
Pfami | PF00452. Bcl-2. 1 hit. PF02180. BH4. 1 hit. [Graphical view] |
SMARTi | SM00265. BH4. 1 hit. [Graphical view] |
PROSITEi | PS50062. BCL2_FAMILY. 1 hit. PS01080. BH1. 1 hit. PS50063. BH4_2. 1 hit. [Graphical view] |
i Sequence
Sequence statusi: Complete.
P41958-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTRCTADNSL TNPAYRRRTM ATGEMKEFLG IKGTEPTDFG INSDAQDLPS
60 70 80 90 100
PSRQASTRRM SIGESIDGKI NDWEEPRLDI EGFVVDYFTH RIRQNGMEWF
110 120 130 140 150
GAPGLPCGVQ PEHEMMRVMG TIFEKKHAEN FETFCEQLLA VPRISFSLYQ
160 170 180 190 200
DVVRTVGNAQ TDQCPMSYGR LIGLISFGGF VAAKMMESVE LQGQVRNLFV
210 220 230 240 250
YTSLFIKTRI RNNWKEHNRS WDDFMTLGKQ MKEDYERAEA EKVGRRKQNR
260 270 280
RWSMIGAGVT AGAIGIVGVV VCGRMMFSLK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L26545 Genomic DNA. Translation: AAA20080.1. Z29443 Genomic DNA. Translation: CAA82573.2. |
PIRi | A53189. H88578. |
RefSeqi | NP_499284.1. NM_066883.5. |
UniGenei | Cel.6305. |
Genome annotation databases
EnsemblMetazoai | T07C4.8; T07C4.8; WBGene00000423. |
GeneIDi | 3565776. |
KEGGi | cel:CELE_T07C4.8. |
UCSCi | T07C4.8.1. c. elegans. |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L26545 Genomic DNA. Translation: AAA20080.1. Z29443 Genomic DNA. Translation: CAA82573.2. |
PIRi | A53189. H88578. |
RefSeqi | NP_499284.1. NM_066883.5. |
UniGenei | Cel.6305. |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated |
| ||||||||||||||||||||||||
ProteinModelPortali | P41958. | ||||||||||||||||||||||||
SMRi | P41958. Positions 71-236. | ||||||||||||||||||||||||
ModBasei | Search... | ||||||||||||||||||||||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 533094. 4 interactions. |
DIPi | DIP-250N. |
IntActi | P41958. 3 interactions. |
MINTi | MINT-1526902. |
STRINGi | 6239.T07C4.8. |
Protein family/group databases
TCDBi | 1.A.21.2.1. the bcl-2 (bcl-2) family. |
Proteomic databases
PaxDbi | P41958. |
PRIDEi | P41958. |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
EnsemblMetazoai | T07C4.8; T07C4.8; WBGene00000423. |
GeneIDi | 3565776. |
KEGGi | cel:CELE_T07C4.8. |
UCSCi | T07C4.8.1. c. elegans. |
Organism-specific databases
CTDi | 3565776. |
WormBasei | T07C4.8; CE25104; WBGene00000423; ced-9. |
Phylogenomic databases
eggNOGi | NOG326862. |
HOGENOMi | HOG000111534. |
InParanoidi | P41958. |
OMAi | YVEVVEC. |
OrthoDBi | EOG764748. |
PhylomeDBi | P41958. |
Miscellaneous databases
EvolutionaryTracei | P41958. |
NextBioi | 957817. |
PROi | P41958. |
Family and domain databases
InterProi | IPR002475. Bcl2-like. IPR020717. Bcl2_BH1_motif_CS. IPR003093. Bcl2_BH4. IPR026298. Blc2_fam. [Graphical view] |
PANTHERi | PTHR11256. PTHR11256. 1 hit. |
Pfami | PF00452. Bcl-2. 1 hit. PF02180. BH4. 1 hit. [Graphical view] |
SMARTi | SM00265. BH4. 1 hit. [Graphical view] |
PROSITEi | PS50062. BCL2_FAMILY. 1 hit. PS01080. BH1. 1 hit. PS50063. BH4_2. 1 hit. [Graphical view] |
ProtoNeti | Search... |
Publicationsi
- "C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2."
Hengartner M.O., Horvitz H.R.
Cell 76:665-676(1994) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.Strain: Bristol N2. - "Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].Strain: Bristol N2. - "Interaction between the C. elegans cell-death regulators CED-9 and CED-4."
Spector M.S., Desnoyers S., Hoeppner D.J., Hengartner M.O.
Nature 385:653-656(1997) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, DEVELOPMENTAL STAGE, MUTAGENESIS OF TYR-149 AND GLY-169.Strain: Bristol N2. - "Interaction and regulation of subcellular localization of CED-4 by CED-9."
Wu D., Wallen H.D., Nunez G.
Science 275:1126-1129(1997) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CED-4. - "The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9."
Conradt B., Horvitz H.R.
Cell 93:519-529(1998) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH EGL-1. - "Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death."
Chen F., Hersh B.M., Conradt B., Zhou Z., Riemer D., Gruenbaum Y., Horvitz H.R.
Science 287:1485-1489(2000) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION. - "Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma."
Chiorazzi M., Rui L., Yang Y., Ceribelli M., Tishbi N., Maurer C.W., Ranuncolo S.M., Zhao H., Xu W., Chan W.C., Jaffe E.S., Gascoyne R.D., Campo E., Rosenwald A., Ott G., Delabie J., Rimsza L.M., Shaham S., Staudt L.M.
Proc. Natl. Acad. Sci. U.S.A. 110:3943-3948(2013) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH DRE-1. - "Unique structural features of a BCL-2 family protein CED-9 and biophysical characterization of CED-9/EGL-1 interactions."
Woo J.-S., Jung J.-S., Ha N.-C., Shin J., Kin K.-H., Lee W., Oh B.-H.
Cell Death Differ. 10:1310-1319(2003) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS) OF 68-242 IN COMPLEX WITH EGL-1. - "Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4."
Yan N., Gu L., Kokel D., Chai J., Li W., Han A., Chen L., Xue D., Shi Y.
Mol. Cell 15:999-1006(2004) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 68-237 IN COMPLEX WITH EGL-1, FUNCTION, INTERACTION WITH EGL-1 AND CED-4.
Entry informationi
Entry namei | CED9_CAEEL | ||||||||
Accessioni | P41958Primary (citable) accession number: P41958 | ||||||||
Entry historyi |
| ||||||||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Caenorhabditis elegansCaenorhabditis elegans: entries, gene names and cross-references to WormBase
- PDB cross-referencesIndex of Protein Data Bank (PDB) cross-references
- SIMILARITY commentsIndex of protein domains and families
External Data
Dasty 3Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry. |
90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |