Depersonalization on HRT?

clumsycolours · 11時間前

If you don't feel well on too much AA try lowering the dose. T is responsible for some kind of drive. Be sure to inform your doc.

For reference: my doc told my I should up/down my AA dose and try what feels best.

gegenny · 7時間前

So, in my experience, dutasteride/avodart caused me in very short order to relapse into severe depression. It's not typically what is prescribed as an AA (at least in the US). It's generally for prostate issues or hair loss. Finasteride is a similar drug, often used for the same things, but generally fewer side effects (though even that has been reported to cause depression/fogginess).

Is there a particular reason you're on Avodart and not one of the more common anti-androgens? (aldactone/cypretone acetate (non-US)/lupron (GnRH agonists, expensive and less common))

dnytm · 6時間前

Not to downplay how you feel, but have you been diagnosed with depersonalizations? I've had episodes of it due to anxiety disorder + stress and it's (usually) different from how you're explaining it. Yours sounds closer to normal depression?

I only ask because it's good to be as close to 100% sure of what you're dealing with when trying to fix it.

April_From_Now_On · 7時間前

I'm on 200mg of Spiro and 4mg of estrace. I've been trying on and off to take the estrace sublingually to give my liver a break. But every single time I do, I experience severe dysphoria and symptoms like the ones you mentioned.

Ebomb1 · 9時間前

For me, at least, operating in crisis mode floods me with motivation. Consistently, when I improve my life by taking away one of the things that used to keep me in crisis mode 24/7, everything goes flat. I have to consciously work to rebuild my motivation around more normal levels of emotion, instead of relying on being overstimulated enough to operate by rote.

I agree with the others--get your levels checked, maybe consider anti-Ds/anti-As. But also consider in addition that maybe your brain just doesn't know what to do with itself since it's not used to not being overstressed.

hanazon0 · 8時間前

its the AA...

olivias1988 · 4時間前

Like /u/gegenny and /u/hanazon0 both mentioned you should look into a different anti androgen (some people actually get increased serum T in their system on it!). Firstly dutasteride (aka avodart) is not a true anti androgen. It is a 5-alpha reductase inhibitor so it prevents the production of DHT and many other functions. Some people get bad side effects from this. 5-alpha reductase is an important chemical in your body. I am not going to go into it, I am not a doctor. It is just something you might consider doing, especially given you said you feel beter sometimes when you don't take it.

ryl411 · 1時間前

I have not started yet, hopefully on Wednesday I will, so I have no first hand knowledge on this I do however have some academic knowledge on the topic. What you are doing is going through a puberty let it be for your first or second time. As this this is a medically "induced" puberty talk to your doctors, you should not screw around with your doses yourself.

fairtonoone · 55分前

I used a similar antiandrogen for some time and had depersonalisation from it, it was living hell :( definately the antiandrogen, switch it (as it is also not a real AA). The functions of the 5-alpha-reductase aren´t completely known in the brain, so apparantly this is quiete common. My mind returned after a few months of stopping those inhibitors and continuing with normal hrt (cyproterone acetate and estrifam, later with leuproreline)

hoping4rein · 34分前

I've experienced the same thing. I'm 6 years into hrt and even though I feel like I'm more comfortable in my skin and could never go back, I've had no drive or enjoyment since starting. I'm only on 50mg/day of spiro, yet my T levels are below the average female range, which may have something to do with it, but I don't know. I worry that I'll never feel energized or motivated again at this point.

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