Q9P2E2 (KIF17_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
July 9, 2014.
Version 114.
History...
Names and origin
Protein names | Recommended name: Kinesin-like protein KIF17 Alternative name(s): KIF3-related motor protein | ||||
Gene names |
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Organism | Homo sapiens (Human) [Reference proteome] | ||||
Taxonomic identifier | 9606 [NCBI] | ||||
Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
Sequence length | 1029 AA. |
Sequence status | Complete. |
Protein existence | Evidence at transcript level |
General annotation (Comments)
Function | Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules By similarity. |
Subunit structure | Interacts with LIN-10 PDZ domain. Interacts with PIWIL1 By similarity. Interacts with TBATA By similarity. |
Subcellular location | Cytoplasm › cytoskeleton Probable. |
Sequence similarities | Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Contains 1 kinesin motor domain. |
Sequence caution | The sequence AAD01428.1 differs from that shown. Reason: Frameshift at positions 970 and 990. The sequence AAD01428.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part. The sequence AAH36871.1 differs from that shown. Reason: Cloning artifact. The sequence BAA92643.2 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part. The sequence CAH73471.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI23390.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
Alternative products
This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
Isoform 1 (identifier: Q9P2E2-1) Also known as: KIF17b; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
Isoform 2 (identifier: Q9P2E2-3) The sequence of this isoform differs from the canonical sequence as follows: 908-908: Missing. |
Sequence annotation (Features)
Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
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Chain | 1 – 1029 | 1029 | Kinesin-like protein KIF17 | PRO_0000125450 | |||||
Regions | |||||||||
Domain | 5 – 335 | 331 | Kinesin motor | ||||||
Nucleotide binding | 91 – 98 | 8 | ATP By similarity | ||||||
Coiled coil | 346 – 462 | 117 | Potential | ||||||
Coiled coil | 739 – 846 | 108 | Potential | ||||||
Natural variations | |||||||||
Alternative sequence | 908 | 1 | Missing in isoform 2. | VSP_040346 | |||||
Natural variant | 341 | 1 | I → V. Corresponds to variant rs2296225 [ dbSNP | Ensembl ]. | VAR_055983 | |||||
Natural variant | 369 | 1 | S → R. Corresponds to variant rs56750936 [ dbSNP | Ensembl ]. | VAR_061282 | |||||
Natural variant | 402 | 1 | V → M. Ref.1 Ref.3 Ref.4 Corresponds to variant rs522496 [ dbSNP | Ensembl ]. | VAR_023527 | |||||
Natural variant | 675 | 1 | V → I. Corresponds to variant rs558760 [ dbSNP | Ensembl ]. | VAR_055984 | |||||
Natural variant | 735 | 1 | V → I. Corresponds to variant rs13375609 [ dbSNP | Ensembl ]. | VAR_055985 | |||||
Natural variant | 933 | 1 | D → E. Ref.1 Ref.3 Ref.4 Ref.6 Corresponds to variant rs631357 [ dbSNP | Ensembl ]. | VAR_023528 | |||||
Experimental info | |||||||||
Sequence conflict | 925 | 1 | D → Y in AAD01428. Ref.6 | ||||||
Sequence conflict | 957 | 1 | R → W in AAR33039. Ref.1 | ||||||
Sequence conflict | 957 | 1 | R → W in BAA92643. Ref.4 |
Sequences
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References
« Hide 'large scale' references | |
[1] | "The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells." Chennathukuzhi V., Morales C.R., El-Alfy M., Hecht N.B. Proc. Natl. Acad. Sci. U.S.A. 100:15566-15571(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-402 AND GLU-933. |
[2] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
[3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS MET-402 AND GLU-933. Tissue: Eye. |
[4] | "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-1029 (ISOFORM 1), VARIANTS MET-402 AND GLU-933. Tissue: Brain. |
[5] | Ohara O., Nagase T., Kikuno R. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION. |
[6] | "The MAP kinase kinase kinases MLK2 and MLK3 are targets for RAC/Cdc42 and components of microtubule motor complexes." Nagata K., Puls A., Futter C., Aspenstroem P., Hall A. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 793-1029, VARIANT GLU-933. |
+ | Additional computationally mapped references. |
Cross-references
Sequence databases | |
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EMBL GenBank DDBJ | AY484427 mRNA. Translation: AAR33039.1. AL391357, AL663074 Genomic DNA. Translation: CAH73471.1. Sequence problems. AL663074, AL391357 Genomic DNA. Translation: CAI23390.1. Sequence problems. AL391357, AL663074 Genomic DNA. Translation: CAM12849.1. AL663074, AL391357 Genomic DNA. Translation: CAM12853.1. AL391357, AL663074 Genomic DNA. Translation: CAM12850.1. AL663074, AL391357 Genomic DNA. Translation: CAM12852.1. BC036871 mRNA. Translation: AAH36871.1. Sequence problems. BC065927 mRNA. Translation: AAH65927.1. AB037826 mRNA. Translation: BAA92643.2. Sequence problems. AF009624 mRNA. Translation: AAD01428.1. Sequence problems. |
CCDS | CCDS213.1. [Q9P2E2-1] CCDS44079.1. [Q9P2E2-3] |
RefSeq | NP_001116291.1. NM_001122819.2. [Q9P2E2-3] NP_001274141.1. NM_001287212.1. NP_065867.2. NM_020816.3. [Q9P2E2-1] |
UniGene | Hs.130411. |
3D structure databases | |
ProteinModelPortal | Q9P2E2. |
SMR | Q9P2E2. Positions 3-353. |
ModBase | Search... |
MobiDB | Search... |
Protein-protein interaction databases | |
BioGrid | 121629. 3 interactions. |
IntAct | Q9P2E2. 3 interactions. |
MINT | MINT-2875280. |
STRING | 9606.ENSP00000247986. |
PTM databases | |
PhosphoSite | Q9P2E2. |
Polymorphism databases | |
DMDM | 317373436. |
Proteomic databases | |
MaxQB | Q9P2E2. |
PaxDb | Q9P2E2. |
PRIDE | Q9P2E2. |
Protocols and materials databases | |
StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
Ensembl | ENST00000247986; ENSP00000247986; ENSG00000117245. [Q9P2E2-1] ENST00000400463; ENSP00000383311; ENSG00000117245. [Q9P2E2-3] |
GeneID | 57576. |
KEGG | hsa:57576. |
UCSC | uc001bdr.4. human. [Q9P2E2-1] uc001bds.4. human. [Q9P2E2-3] |
Organism-specific databases | |
CTD | 57576. |
GeneCards | GC01M020990. |
H-InvDB | HIX0000220. |
HGNC | HGNC:19167. KIF17. |
HPA | HPA032085. |
MIM | 605037. gene. |
neXtProt | NX_Q9P2E2. |
PharmGKB | PA38809. |
HUGE | Search... |
GenAtlas | Search... |
Phylogenomic databases | |
eggNOG | COG5059. |
HOVERGEN | HBG052255. |
InParanoid | Q9P2E2. |
KO | K10394. |
OMA | FWKIPEP. |
OrthoDB | EOG7WX086. |
PhylomeDB | Q9P2E2. |
TreeFam | TF105223. |
Gene expression databases | |
Bgee | Q9P2E2. |
CleanEx | HS_KIF17. |
Genevestigator | Q9P2E2. |
Family and domain databases | |
Gene3D | 3.40.850.10. 1 hit. |
InterPro | IPR027640. Kinesin-like_fam. IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. IPR027417. P-loop_NTPase. [Graphical view] |
PANTHER | PTHR24115. PTHR24115. 1 hit. |
Pfam | PF00225. Kinesin. 1 hit. [Graphical view] |
PRINTS | PR00380. KINESINHEAVY. |
SMART | SM00129. KISc. 1 hit. [Graphical view] |
SUPFAM | SSF52540. SSF52540. 1 hit. |
PROSITE | PS00411. KINESIN_MOTOR_1. 1 hit. PS50067. KINESIN_MOTOR_2. 1 hit. [Graphical view] |
ProtoNet | Search... |
Other | |
GeneWiki | KIF17. |
GenomeRNAi | 57576. |
NextBio | 64119. |
PRO | Q9P2E2. |
SOURCE | Search... |
Entry information
Entry name | KIF17_HUMAN | ||||||||
Accession | Primary (citable) accession number: Q9P2E2 Secondary accession number(s): A2A3Q7 | ||||||||
Entry history |
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Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Annotation program | Chordata Protein Annotation Program | ||||||||
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Relevant documents
SIMILARITY comments Index of protein domains and families |
MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |