技術紹介

ホーム技術紹介|論文紹介

論文紹介

REFERENCES / PUBLICATIONS

Cell-sheet technology references / publications(細胞シート工学)

Kikuchi, A., Okuhara. M., Karikusa. F., Sakurai. Y., and Okano. T. (1998). Two-dimensional manipulation of confluently cultured vascular endothelial cells using temperature-responsive poly(N-isopropylacrylamide)-grafted surfaces. Journal of Biomaterials Science, Polymer Edition 9(12), 1331-1348.
Okano, T., Yamada, N., Okuhara, M., Sakai, H., and Sakurai, Y. (1995). Mechanism of cell detachment from temperature-modulated, hydrophilic-hydrophobic polymer surfaces. Biomaterials 16, 297-303.
Yamada, N., Okano, T., Sakai, H., Karikusa, F., Sawasaki, Y., and Sakurai, Y. (1990). Thermo-responsive polymeric surfaces; control of attachment and detachment of cultured cells. Die Makromolekulare Chemie, Rapid Communication 11, 571-576.

Surface modification references / publications (細胞培養皿表面技術関連)

Elloumi-Hannachi, I., Maeda, M., Yamato, M. & Okano, T. (2010) Portable microcontact printing device for cell culture. Biomaterials, 31(34), 8974-8979.
Elloumi-Hannachi, I., Itoga, K., Kumashiro, Y., Kobayashi, J., Yamato, M. & Okano, T. (2009) Fabrication of transferable micropatterned-co-cultured cell sheets with microcontact printing. Biomaterials, 30(29), 5427-5432.
Hannachi, I. E., Yamato, M. & Okano, T. (2009) Cell sheet technology and cell patterning for biofabrication. Biofabrication, 1(2), 022002.
Nagase, K., Kobayashi, J. & Okano, T. (2009) Temperature-responsive intelligent interfaces for biomolecular separation and cell sheet engineering. J R Soc Interface, 6 Suppl 3, S293-309.
Nishi, M., Kobayashi, J., Pechmann, S., Yamato, M., Akiyama, Y., Kikuchi, A., Uchida, K., Textor, M., Yajima, H., and Okano, T. (2007). The use of biotin-avidin binding to facilitate biomodification of thermoresponsive culture surfaces. Biomaterials 28, 5471-5476.
Tsuda, Y., Shimizu, T., Yamato, M., Kikuchi, A., Sasagawa, T., Sekiya, S., Kobayashi, J., Chen, G., and Okano, T. (2007). Cellular control of tissue architectures using a three-dimensional tissue fabrication technique. Biomaterials 28, 4939-4946.
Hatakeyama, H., Kikuchi, A., Yamato, M., and Okano, T. (2006). Bio-functionalized thermoresponsive interfaces facilitating cell adhesion and proliferation. Biomaterials 27, 5069-5078.
Hatakeyama, H., Kikuchi, A., Yamato, M., and Okano, T. (2005). Influence of insulin immobilization to thermoresponsive culture surfaces on cell proliferation and thermally induced cell detachment. Biomaterials 26, 5167-5176.
Ebara, M., Yamato, M., Aoyagi, T., Kikuchi, A., Sakai, K., and Okano, T. (2004). Immobilization of cell-adhesive peptides to temperature-responsive surfaces facilitates both serum-free cell adhesion and noninvasive cell harvest. Tissue engineering 10, 1125-1135.
Ebara, M., Yamato, M., Aoyagi, T., Kikuchi, A., Sakai, K., and Okano, T. (2004). Temperature-responsive cell culture surfaces enable "on-off" affinity control between cell integrins and RGDS ligands. Biomacromolecules 5, 505-510.
Ebara, M., Yamato, M., Hirose, M., Aoyagi, T., Kikuchi, A., Sakai, K., and Okano, T. (2003). Copolymerization of 2-carboxyisopropylacrylamide with N-isopropylacrylamide accelerates cell detachment from grafted surfaces by reducing temperature. Biomacromolecules 4, 344-349.
Kwon, O.H., Kikuchi, A., Yamato, M., and Okano, T. (2003). Accelerated cell sheet recovery by co-grafting of PEG with PIPAAm onto porous cell culture membranes. Biomaterials 24, 1223-1232.
Kwon, O.H., Kikuchi, A., Yamato, M., Sakurai, Y., and Okano, T. (2000). Rapid cell sheet detachment from poly(N-isopropylacrylamide)-grafted porous cell culture membranes. Journal of biomedical materials research 50, 82-89.
Yamato, M., Konno, C., Kushida, A., Hirose, M., Utsumi, M., Kikuchi, A., and Okano, T. (2000). Release of adsorbed fibronectin from temperature-responsive culture surfaces requires cellular activity. Biomaterials 21, 981-986.
Uchida, K., Sakai, K., Ito, E., Kwon, O.H., Kikuchi, A., Yamato, M., and Okano, T. (2000). Temperature-dependent modulation of blood platelet movement and morphology on poly(N-isopropylacrylamide)-grafted surfaces. Biomaterials 21, 923-929.

UpCell references / publicationsnew

Cornea(角膜)

Kocaba, V., Thepot, A., Yamato, M., Daisuke, M., Kellal, M., Mojallal, A., Damour, O., & Burillon, C. (2014) Long-Term Results of Cultured Autologous Oral Mucosa Epithelial Cell-Sheet (CAOMECS) Graft for the Treatment of Blindness Due to Bilateral Limbal Stem Cell Deficiency. J Stem Cell Res Ther 4(3):181
Burillon, C., Huot, L., Justin, V., Nataf, S., Chapuis, F., Decullier, E., & Damour, O. (2012) Cultured autologous oral mucosal epithelial cell sheet (CAOMECS) transplantation for the treatment of corneal limbal epithelial stem cell deficiency. Investigative Ophthalmology & Visual Science, 53(3), 1325-31.
Takagi, R., Yamato, M., Murakami, D., Kondo, M., Yang, J., Ohki, T., Nishida, K., Kohno, C. & Okano, T. (2011) Preparation of keratinocyte culture medium for the clinical applications of regenerative medicine. J Tissue Eng Regen Med, 5(4), e63-73.
Thepot, A., Morel, A. P., Justin, V., Desanlis, A., Thivillier, L., Hoffman, E., Till, M., Accardi, R., Tommasino, M., Breton, P., Hainaut, P. & Damour, O. (2010) Evaluation of tumorigenic risk of tissue-engineered oral mucosal epithelial cells by using combinational examinations. Cell Transplant, 19(8), 999-1006.
Hayashi, R., Yamato, M., Takayanagi, H., Oie, Y., Kubota, A., Hori, Y., Okano, T. & Nishida, K. (2010) Validation system of tissue-engineered epithelial cell sheets for corneal regenerative medicine. Tissue Eng Part C Methods, 16(4), 553-560.
Watanabe, K., Yamato, M., Hayashida, Y., Yang, J., Kikuchi, A., Okano, T., Tano, Y., and Nishida, K. (2007). Development of transplantable genetically modified corneal epithelial cell sheets for gene therapy. Biomaterials 28, 745-749.
Obokata, H., Yamato, M., Yang, J., Nishida, K., Tsuneda, S., and Okano, T. (2007). Subcutaneous transplantation of autologous oral mucosal epithelial cell sheets fabricated on temperature-responsive culture dishes. Journal of biomedical materials research. Part A
Kanayama, S., Nishida, K., Yamato, M., Hayashi, R., Sugiyama, H., Soma, T., Maeda, N., Okano, T., and Tano, Y. (2007). Analysis of angiogenesis induced by cultured corneal and oral mucosal epithelial cell sheets in vitro. Experimental eye research 85, 772-781.
Sumide, T., Nishida, K., Yamato, M., Ide, T., Hayashida, Y., Watanabe, K., Yang, J., Kohno, C., Kikuchi, A., Maeda, N., Watanabe, H., Okano, T. and Tano, Y. (2006). Functional human corneal endothelial cell sheets harvested from temperature-responsive culture surfaces. The FASEB Journal 20, 392-394.
Ide, T., Nishida, K., Yamato, M., Sumide, T., Utsumi, M., Nozaki, T., Kikuchi, A., Okano, T., and Tano, Y. (2006). Structural characterization of bioengineered human corneal endothelial cell sheets fabricated on temperature-responsive culture dishes. Biomaterials 27, 607-614.
Hayashida, Y., Nishida, K., Yamato, M., Yang, J., Sugiyama, H., Watanabe, K., Hori, Y., Maeda, N., Kikuchi, A., Okano, T. and Tano, Y. (2006). Transplantation of tissue-engineered epithelial cell sheets after excimer laser photoablation reduces postoperative corneal haze. Investigative ophthalmology & visual science 47, 552-557.
Umemoto, T., Yamato, M., Nishida, K., Kohno, C., Yang, J., Tano, Y., and Okano, T. (2005). Rat limbal epithelial side population cells exhibit a distinct expression of stem cell markers that are lacking in side population cells from the central cornea. FEBS letters 579, 6569-6574.
Hayashida, Y., Nishida, K., Yamato, M., Watanabe, K., Maeda, N., Watanabe, H., Kikuchi, A., Okano, T., and Tano, Y. (2005). Ocular surface reconstruction using autologous rabbit oral mucosal epithelial sheets fabricated ex vivo on a temperature-responsive culture surface. Investigative ophthalmology & visual science 46, 1632-1639.
Watanabe, K., Nishida, K., Yamato, M., Umemoto, T., Sumide, T., Yamamoto, K., Maeda, N., Watanabe, H., Okano, T., and Tano, Y. (2004). Human limbal epithelium contains side population cells expressing the ATP-binding cassette transporter ABCG2. FEBS letters 565, 6-10.
Nishida, K., Yamato, M., Hayashida, Y., Watanabe, K., Yamamoto, K., Adachi, E., Nagai, S., Kikuchi, A., Maeda, N., Watanabe, H., Okano, T. and Tano, Y. (2004). Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium. The New England journal of medicine 351, 1187-1196.
Nishida, K., Yamato, M., Hayashida, Y., Watanabe, K., Maeda, N., Watanabe, H., Yamamoto, K., Nagai, S., Kikuchi, A., Tano, Y. and Okano, T. (2004). Functional bioengineered corneal epithelial sheet grafts from corneal stem cells expanded ex vivo on a temperature-responsive cell culture surface. Transplantation 77, 379-385.

Cardiac myoblast(心筋)

Siltanen, A., Kitabayashi, K., Lakkisto, P., Makela, J., Patila, T., Ono, M., Tikkanen, I., Sawa, Y., Kankuri, E. & Harjula, A. (2011) Hhgf overexpression in myoblast sheets enhances their angiogenic potential in rat chronic heart failure. PLoS One, 6(4), e19161.
Siltanen, A., Kitabayashi, K., Patila, T., Ono, M., Tikkanen, I., Sawa, Y., Kankuri, E. & Harjula, A. (2011) Bcl-2 improves myoblast sheet therapy in rat chronic heart failure. Tissue Eng Part A, 17(1-2), 115-125.
Haraguchi, Y., Shimizu, T., Yamato, M. & Okano, T. (2010) Electrical interaction between cardiomyocyte sheets separated by non-cardiomyocyte sheets in heterogeneous tissues. J Tissue Eng Regen Med, 4(4), 291-299.
Hata, H., Bar, A., Dorfman, S., Vukadinovic, Z., Sawa, Y., Haverich, A. & Hilfiker, A. (2010) Engineering a novel three-dimensional contractile myocardial patch with cell sheets and decellularised matrix. Eur J Cardiothorac Surg, 38(4), 450-455.
Kitabayashi, K., Siltanen, A., Patila, T., Mahar, M. A., Tikkanen, I., Koponen, J., Ono, M., Sawa, Y., Kankuri, E. & Harjula, A. (2010) Bcl-2 expression enhances myoblast sheet transplantation therapy for acute myocardial infarction. Cell Transplant, 19(5), 573-588.
Shimizu, K., Fujita, H. & Nagamori, E. (2010) Micropatterning of single myotubes on a thermoresponsive culture surface using elastic stencil membranes for single-cell analysis. J Biosci Bioeng, 109(2), 174-178.
Shimizu, T., Sekine, H., Yamato, M. & Okano, T. (2009) Cell sheet-based myocardial tissue engineering: New hope for damaged heart rescue. Curr Pharm Des, 15(24), 2807-2814.
Matsuura, K., Honda, A., Nagai, T., Fukushima, N., Iwanaga, K., Tokunaga, M., Shimizu, T., Okano, T., Kasanuki, H., Hagiwara, N. & Komuro, I. (2009) Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice. J Clin Invest, 119(8), 2204-2217.
Sasagawa, T., Shimizu, T., Sekiya, S., Haraguchi, Y., Yamato, M., Sawa, Y. & Okano, T. (2010) Design of prevascularized three-dimensional cell-dense tissues using a cell sheet stacking manipulation technology. Biomaterials, 31(7), 1646-1654.
Okura, H., Matsuyama, A., Lee, C. M., Saga, A., Kakuta-Yamamoto, A., Nagao, A., Sougawa, N., Sekiya, N., Takekita, K., Shudo, Y., Miyagawa, S., Komoda, H., Okano, T. & Sawa, Y. (2009) Cardiomyoblast-like cells differentiated from human adipose tissue-derived mesenchymal stem cells improve left ventricular dysfunction and survival in a rat myocardial infarction model. Tissue Eng Part C Methods, 16(3), 417-425.
Sekiya, N., Matsumiya, G., Miyagawa, S., Saito, A., Shimizu, T., Okano, T., Kawaguchi, N., Matsuura, N. & Sawa, Y. (2009) Layered implantation of myoblast sheets attenuates adverse cardiac remodeling of the infarcted heart. J Thorac Cardiovasc Surg, 138(4), 985-993.
Masuda, S., Shimizu, T., Yamato, M., and Okano, T. (2008). Cell sheet engineering for heart tissue repair. Advanced drug delivery reviews 60, 277-285.
Shimizu, T., Sekine, H., Yang, J., Isoi, Y., Yamato, M., Kikuchi, A., Kobayashi, E., and Okano, T. (2006). Polysurgery of cell sheet grafts overcomes diffusion limits to produce thick, vascularized myocardial tissues. The FASEB journal 20, 708-710.
Shimizu, T., Sekine, H., Isoi, Y., Yamato, M., Kikuchi, A., and Okano, T. (2006). Long-term survival and growth of pulsatile myocardial tissue grafts engineered by the layering of cardiomyocyte sheets. Tissue engineering 12, 499-507.
Sekine, H., Shimizu, T., Yang, J., Kobayashi, E., and Okano, T. (2006). Pulsatile myocardial tubes fabricated with cell sheet engineering. Circulation 114, I87-93.
Sekiya, S., Shimizu, T., Yamato, M., Kikuchi, A., and Okano, T. (2006). Bioengineered cardiac cell sheet grafts have intrinsic angiogenic potential. Biochemical and biophysical research communications 341, 573-582.
Sekine, H., Shimizu, T., Kosaka, S., Kobayashi, E., and Okano, T. (2006). Cardiomyocyte bridging between hearts and bioengineered myocardial tissues with mesenchymal transition of mesothelial cells. J Heart Lung Transplant 25, 324-332.
Haraguchi, Y., Shimizu, T., Yamato, M., Kikuchi, A., and Okano, T. (2006). Electrical coupling of cardiomyocyte sheets occurs rapidly via functional gap junction formation. Biomaterials 27, 4765-4774.
Furuta, A., Miyoshi, S., Itabashi, Y., Shimizu, T., Kira, S., Hayakawa, K., Nishiyama, N., Tanimoto, K., Hagiwara, Y., Satoh, T., Fukada, K., Okano, T. and Ogawa, S. (2006). Pulsatile cardiac tissue grafts using a novel three-dimensional cell sheet manipulation technique functionally integrates with the host heart, in vivo. Circulation research 98, 705-712.
Itabashi, Y., Miyoshi, S., Yuasa, S., Fujita, J., Shimizu, T., Okano, T., Fukuda, K., and Ogawa, S. (2005). Analysis of the electrophysiological properties and arrhythmias in directly contacted skeletal and cardiac muscle cell sheets. Cardiovascular research 67, 561-570.
Miyagawa, S., Sawa, Y., Sakakida, S., Taketani, S., Kondoh, H., Memon, I.A., Imanishi, Y., Shimizu, T., Okano, T., and Matsuda, H. (2005). Tissue cardiomyoplasty using bioengineered contractile cardiomyocyte sheets to repair damaged myocardium: their integration with recipient myocardium. Transplantation 80, 1586-1595.
Shimizu, T., Yamato, M., Kikuchi, A., and Okano, T. (2003). Cell sheet engineering for myocardial tissue reconstruction. Biomaterials 24, 2309-2316.
Shimizu, T., Yamato, M., Isoi, Y., Akutsu, T., Setomaru, T., Abe, K., Kikuchi, A., Umezu, M., and Okano, T. (2002). Fabrication of pulsatile cardiac tissue grafts using a novel 3-dimensional cell sheet manipulation technique and temperature-responsive cell culture surfaces. Circulation research 90, e40-e48.
Shimizu, T., Yamato, M., Akutsu, T., Shibata, T., Isoi, Y., Kikuchi, A., Umezu, M., and Okano, T. (2002). Electrically communicating three-dimensional cardiac tissue mimic fabricated by layered cultured cardiomyocyte sheets. Journal of biomedical materials research 60, 110-117.
Shimizu, T., Yamato, M., Kikuchi, A., and Okano, T. (2001). Two-dimensional manipulation of cardiac myocyte sheets utilizing temperature-responsive culture dishes augments the pulsatile amplitude. Tissue Engineering 7, 141-151.

Chondrocyte(軟骨)

Sato M. (2010) Cell sheet technologies for cartilage repair, Regenerative medicine and biomaterials for the repair of connective tissues. (Edited by Archer C and Ralphs J) WOODHEAD Publishing Limited, CRC Press LLC, 251-265.
Mitani, G., Sato, M., Lee, J. I., Kaneshiro, N., Ishihara, M., Ota, N., Kokubo, M., Sakai, H., Kikuchi, T. & Mochida, J. (2009) The properties of bioengineered chondrocyte sheets for cartilage regeneration. BMC Biotechnol 6, 9-17.
Sato, M., lshihara, M., Furukawa, K., Kaneshiro, N., Nagai, T., Mitani, G., Kutsuna, T., 0hta, N., Kokubo, M., Kikuchi, T., Sakai, H., Ushida, T., Kikuchi, M. and Mochida, J. (2008) Recent technological advancements related to articular cartilage regeneration. Med BioI Eng Comput 46, 735-743
Kaneshiro. N., Sato. M., Ishihara. M., Mitani. G., Sakai. H., Kikuchi. T. and Mochida. J. (2007). Cultured articular chondrocytes sheets for partial thickness cartilage defects utilizing temperature-responsive culture dishes. European Cells and Materials 13, 87-92.
Kaneshiro, N., Sato, M., Ishihara, M., Mitani, G., Sakai, H., and Mochida, J. (2006). Bioengineered chondrocyte sheets may be potentially useful for the treatment of partial thickness defects of articular cartilage. Biochemical and biophysical research communications 349, 723-731.

Esophagus cancer(食道がん)

Ohki, T., Yamamoto, M., Ota, M., Okano, T. & Yamamoto, M. (2011) Application of cell sheet technology for esophageal endoscopic submucosal dissection. Tech Gastrointest Endosc, 13(1), 105-109.
Takagi, R., Murakami, D., Kondo, M., Ohki, T., Sasaki, R., Mizutani, M., Yamato, M., Nishida, K., Namiki, H., Yamamoto, M. & Okano, T. (2010) Fabrication of human oral mucosal epithelial cell sheets for treatment of esophageal ulceration by endoscopic submucosal dissection. Gastrointest Endosc, 72(6), 1253-1259.
Ohki, T., Yamato, M., Murakami, D., Takagi, R., Yang, J., Namiki, H., Okano, T., and Takasaki, K. (2006). Treatment of oesophageal ulcerations using endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets in a canine model. Gut 55, 1704-1710.
Murakami, D., Yamato, M., Nishida, K., Ohki, T., Takagi, R., Yang, J., Namiki, H., and Okano, T. (2006). The effect of micropores in the surface of temperature-responsive culture inserts on the fabrication of transplantable canine oral mucosal epithelial cell sheets. Biomaterials 27, 5518-5523.
Murakami, D., Yamato, M., Nishida, K., Ohki, T., Takagi, R., Yang, J., Namiki, H., and Okano, T. (2006). Fabrication of transplantable human oral mucosal epithelial cell sheets using temperature-responsive culture inserts without feeder layer cells. Journal of artificial organs 9, 185-191.

Hepatocyte(肝臓)

Ohno, M., Motojima, K., Okano, T. & Taniguchi, A. (2009) Maturation of the extracellular matrix and cell adhesion molecules in layered co-cultures of hepg2 and endothelial cells. J Biochem, 145(5), 591-597.
Ohno, M., Motojima, K., Okano, T. & Taniguchi, A. (2009) Induction of drug-metabolizing enzymes by phenobarbital in layered co-culture of a human liver cell line and endothelial cells. Biol Pharm Bull, 32(5), 813-817.
Takayama, G., Taniguchi, A., and Okano, T. (2007). Identification of differentially expressed genes in hepatocyte/endothelial cell co-culture system. Tissue engineering 13, 159-166.
Ohashi, K., Yokoyama, T., Yamato, M., Kuge, H., Kanehiro, H., Tsutsumi, M., Amanuma, T., Iwata, H., Yang, J., Okano, T. and Nakajima, Y. (2007). Engineering functional two- and three-dimensional liver systems in vivo using hepatic tissue sheets. Nat Med 13, 880-885.
Kurosawa, Y., Taniguchi, A., and Okano, T. (2005). Novel method to examine hepatocyte-specific gene expression in a functional coculture system. Tissue engineering 11, 1650-1657.
Harimoto, M., Yamato, M., Hirose, M., Takahashi, C., Isoi, Y., Kikuchi, A., and Okano, T. (2002). Novel approach for achieving double-layered cell sheets co-culture: overlaying endothelial cell sheets onto monolayer hepatocytes utilizing temperature-responsive culture dishes. Journal of biomedical materials research 62, 464-470.
Hirose, M., Yamato, M., Kwon, O.H., Harimoto, M., Kushida, A., Shimizu, T., Kikuchi, A., and Okano, T. (2000). Temperature-responsive surface for novel co-culture systems of hepatocytes with endothelial cells: 2-D patterned and double layered co-cultures. Yonsei medical journal 41, 803-813.

Keratinocyte(表皮)

Obokata, H., Yamato, M., Tsuneda, S. & Okano, T. (2011) Reproducible subcutaneous transplantation of cell sheets into recipient mice. Nat Protoc, 6(7), 1053-1059.
Yamato, M., Utsumi, M., Kushida, A., Konno, C., Kikuchi, A., and Okano, T. (2001). Thermo-responsive culture dishes allow the intact harvest of multilayered keratinocyte sheets without dispase by reducing temperature. Tissue engineering 7, 473-480.

Lung(肺)

Kanzaki, M., Yamato, M., Yang, J., Sekine, H., Kohno, C., Takagi, R., Hatakeyama, H., Isaka, T., Okano, T., and Onuki, T. (2007). Dynamic sealing of lung air leaks by the transplantation of tissue engineered cell sheets. Biomaterials 28, 4294-4302.
Kanzaki, M., Yamato, M., Hatakeyama, H., Kohno, C., Yang, J., Umemoto, T., Kikuchi, A., Okano, T., and Onuki, T. (2006). Tissue engineered epithelial cell sheets for the creation of a bioartificial trachea. Tissue engineering 12, 1275-1283.
Nandkumar, M.A., Yamato, M., Kushida, A., Konno, C., Hirose, M., Kikuchi, A., and Okano, T. (2002). Two-dimensional cell sheet manipulation of heterotypically co-cultured lung cells utilizing temperature-responsive culture dishes results in long-term maintenance of differentiated epithelial cell functions. Biomaterials 23, 1121-1130.

MDCK cell(腎臓)

Kushida, A., Yamato, M., Isoi, Y., Kikuchi, A., and Okano, T. (2005). A noninvasive transfer system for polarized renal tubule epithelial cell sheets using temperature-responsive culture dishes. European cells & materials 10, 23-30; discussion 23-30.
Kushida, A., Yamato, M., Kikuchi, A., and Okano, T. (2001). Two-dimensional manipulation of differentiated Madin-Darby canine kidney (MDCK) cell sheets: the noninvasive harvest from temperature-responsive culture dishes and transfer to other surfaces. Journal of biomedical materials research 54, 37-46.
Kushida, A., Yamato, M., Konno, C., Kikuchi, A., Sakurai, Y., and Okano, T. (2000). Temperature-responsive culture dishes allow nonenzymatic harvest of differentiated Madin-Darby canine kidney (MDCK) cell sheets. Journal of biomedical materials research 51, 216-223.

Mesenchymal stem cell(間葉系幹細胞)

Miyahara, Y., Nagaya, N., Kataoka, M., Yanagawa, B., Tanaka, K., Hao, H., Ishino, K., Ishida, H., Shimizu, T., Kangawa, K., Sano, S., Okano, T., Kitamura, S. and Mori, H. (2006). Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nature medicine 12, 459-465.

Microglia(ミクログリア)

Nakajima, K., Honda, S., Nakamura, Y., Lopez-Redondo, F., Kohsaka, S., Yamato, M., Kikuchi, A., and Okano, T. (2001). Intact microglia are cultured and non-invasively harvested without pathological activation using a novel cultured cell recovery method. Biomaterials 22, 1213-1223.

Periodontal ligament(歯根膜)

Izumi, Y., Aoki, A., Yamada, Y., Kobayashi, H., Iwata, T., Akizuki, T., Suda, T., Nakamura, S., Wara-Aswapati, N., Ueda, M. & Ishikawa, I. (2011) Current and future periodontal tissue engineering. Periodontol 2000, 56(1), 166-187.
Tsumanuma, Y., Iwata, T., Washio, K., Yoshida, T., Yamada, A., Takagi, R., Ohno, T., Lin, K., Yamato, M., Ishikawa, I., Okano, T. & Izumi, Y. (2011) Comparison of different tissue-derived stem cell sheets for periodontal regeneration in a canine 1-wall defect model. Biomaterials, 32(25), 5819-5825.
Huang, S. & Zhang, D. (2010) Periodontal ligament cell sheet engineering: A new possible strategy to promote periodontal regeneration of dental implants. Dental Hypotheses, 1(1), 23-30.
Washio, K., Iwata, T., Mizutani, M., Ando, T., Yamato, M., Okano, T. & Ishikawa, I. (2010) Assessment of cell sheets derived from human periodontal ligament cells: A pre-clinical study. Cell Tissue Res, 341(3), 397-404.
Iwata, T., Yamato, M., Zhang, Z., Mukobata, S., Washio, K., Ando, T., Feijen, J., Okano, T. & Ishikawa, I. (2010) Validation of human periodontal ligament-derived cells as a reliable source for cytotherapeutic use. J Clin Periodontol, 37(12), 1088-1099.
Nakagawa, E., Itoh, T., Yoshie, H. & Satokata, I. (2009) Odontogenic potential of post-natal oral mucosal epithelium. J Dent Res, 88(3), 219-223.
Ishikawa, I., Iwata, T., Washio, K., Okano, T., Nagasawa, T., Iwasaki, K. & Ando, T. (2009) Cell sheet engineering and other novel cell-based approaches to periodontal regeneration. Periodontol 2000, 51, 220-238.
Iwata, T., Yamato, M., Tsuchioka, H., Takagi, R., Mukobata, S., Washio, K., Okano, T. & Ishikawa, I. (2009) Periodontal regeneration with multi-layered periodontal ligament-derived cell sheets in a canine model. Biomaterials, 30(14), 2716-2723.
Gomez Flores, M., Hasegawa, M., Yamato, M., Takagi, R., Okano, T., and Ishikawa, I. (2008). Cementum-periodontal ligament complex regeneration using the cell sheet technique. Journal of periodontal research
Hasegawa, M., Yamato, M., Kikuchi, A., Okano, T., and Ishikawa, I. (2005). Human periodontal ligament cell sheets can regenerate periodontal ligament tissue in an athymic rat model. Tissue engineering 11, 469-478.
Akizuki, T., Oda, S., Komaki, M., Tsuchioka, H., Kawakatsu, N., Kikuchi, A., Yamato, M., Okano, T., and Ishikawa, I. (2005). Application of periodontal ligament cell sheet for periodontal regeneration: a pilot study in beagle dogs. Journal of periodontal research 40, 245-251.

Retinal pigment epithelial cell(網膜色素上皮細胞)

Yaji, N., Yamato, M., Yang, J., Okano, T. & Hori, S. (2009) Transplantation of tissue-engineered retinal pigment epithelial cell sheets in a rabbit model. Biomaterials, 30(5), 797-803.
Kubota, A., Nishida, K., Yamato, M., Yang, J., Kikuchi, A., Okano, T., and Tano, Y. (2006). Transplantable retinal pigment epithelial cell sheets for tissue engineering. Biomaterials 27, 3639-3644.
Abe, T., Hojo, M., Saigo, Y., Yamato, M., Okano, T., Wakusawa, R., and Tamai, M. (2006). Retinal pigment epithelial cells from thermally responsive polymer-grafted surface reduce apoptosis. Advances in experimental medicine and biology 572, 363-366.

Skeletal myoblast(骨格筋芽)

Miyagawa, S., Roth, M., Saito, A., Sawa, Y. & Kostin, S. (2011) Tissue-engineered cardiac constructs for cardiac repair. Ann Thorac Surg, 91(1), 320-329.
Miyagawa, S., Saito, A., Sakaguchi, T., Yoshikawa, Y., Yamauchi, T., Imanishi, Y., Kawaguchi, N., Teramoto, N., Matsuura, N., Iida, H., Shimizu, T., Okano, T. & Sawa, Y. (2010) Impaired myocardium regeneration with skeletal cell sheets--a preclinical trial for tissue-engineered regeneration therapy. Transplantation, 90(4), 364-372.
Haraguchi, Y., Sekine, W., Shimizu, T., Yamato, M., Miyoshi, S., Umezawa, A. & Okano, T. (2010) Development of a new assay system for evaluating the permeability of various substances through three-dimensional tissue. Tissue Eng Part C Methods, 16(4), 685-692.
Hoashi, T., Matsumiya, G., Miyagawa, S., Ichikawa, H., Ueno, T., Ono, M., Saito, A., Shimizu, T., Okano, T., Kawaguchi, N., Matsuura, N. & Sawa, Y. (2009) Skeletal myoblast sheet transplantation improves the diastolic function of a pressure-overloaded right heart. J Thorac Cardiovasc Surg, 138(2), 460-467.
Kondoh, H., Sawa, Y., Miyagawa, S., Sakakida-Kitagawa, S., Memon, I.A., Kawaguchi, N., Matsuura, N., Shimizu, T., Okano, T., and Matsuda, H. (2006). Longer preservation of cardiac performance by sheet-shaped myoblast implantation in dilated cardiomyopathic hamsters. Cardiovascular research 69, 466-475.
Hata, H., Matsumiya, G., Miyagawa, S., Kondoh, H., Kawaguchi, N., Matsuura, N., Shimizu, T., Okano, T., Matsuda, H., and Sawa, Y. (2006). Grafted skeletal myoblast sheets attenuate myocardial remodeling in pacing-induced canine heart failure model. The Journal of thoracic and cardiovascular surgery 132, 918-924.
Memon, I.A., Sawa, Y., Fukushima, N., Matsumiya, G., Miyagawa, S., Taketani, S., Sakakida, S.K., Kondoh, H., Aleshin, A.N., Shimizu, T., Okano, T. and Matsuda, H. (2005). Repair of impaired myocardium by means of implantation of engineered autologous myoblast sheets. The Journal of thoracic and cardiovascular surgery 130, 1333-1341.

Smooth muscle cell(平滑筋細胞)

Hobo, K., Shimizu, T., Sekine, H., Shin'oka, T., Okano, T., and Kurosawa, H. (2008). Therapeutic Angiogenesis Using Tissue Engineered Human Smooth Muscle Cell Sheets. Arteriosclerosis, thrombosis, and vascular biology 28, 637-643.

Urothelial cell(尿路上皮細胞)

Shiroyanagi, Y., Yamato, M., Yamazaki, Y., Toma, H., and Okano, T. (2004). Urothelium regeneration using viable cultured urothelial cell sheets grafted on demucosalized gastric flaps. BJU international 93, 1069-1075.
Shiroyanagi, Y., Yamato, M., Yamazaki, Y., Toma, H., and Okano, T. (2003). Transplantable urothelial cell sheets harvested noninvasively from temperature-responsive culture surfaces by reducing temperature. Tissue engineering 9, 1005-1012.

Islet(膵島)

Shimizu. H., Ohashi. K., Utoh. R., Ise. K., Gotoh. M., Yamato. M. and Okano. T. (2009). Bioengineering of a functional sheet of islet cells for the treatment of diabetes mellitus. Biomaterials 30, 5943-5949

Vein endothelial cells(血管内皮細胞)

Sekiya, S., Shimizu, T., Yamato, M. & Okano, T. (2011) "Deep-media culture condition" Promoted lumen formation of endothelial cells within engineered three-dimensional tissues in vitro. J Artif Organs, 14(1), 43-51.
Sekiya, S., Muraoka, M., Sasagawa, T., Shimizu, T., Yamato, M. & Okano, T. (2010) Three-dimensional cell-dense constructs containing endothelial cell-networks are an effective tool for in vivo and in vitro vascular biology research. Microvasc Res, 80(3), 549-551.
Asakawa, N., Shimizu, T., Tsuda, Y., Sekiya, S., Sasagawa, T., Yamato, M., Fukai, F. & Okano, T. (2010) Pre-vascularization of in vitro three-dimensional tissues created by cell sheet engineering. Biomaterials, 31(14), 3903-3909.
Ohno, M., Motojima, K., Okano, T. & Taniguchi, A. (2008) Up-regulation of drug-metabolizing enzyme genes in layered co-culture of a human liver cell line and endothelial cells. Tissue Eng Part A, 14(11), 1861-1869.

Thyroid(甲状腺)

Arauchi, A., Shimizu, T., Yamato, M., Obara, T. & Okano, T. (2009) Tissue-engineered thyroid cell sheet rescued hypothyroidism in rat models after receiving total thyroidectomy comparing with nontransplantation models. Tissue Eng Part A, 15(12), 3943-3949.

Adipose-derived stromal cells(脂肪由来間質細胞)

Hamdi, H., Planat-Benard, V., Bel, A., Puymirat, E., Geha, R., Pidial, L., Nematalla, H., Bellamy, V., Bouaziz, P., Peyrard, S., Casteilla, L., Bruneval, P., Hagege, A. A., Agbulut, O. & Menasche, P. (2011) Epicardial adipose stem cell sheets results in greater post-infarction survival than intramyocardial injections. Cardiovasc Res, 91(3), 483-491.

Bladder(膀胱)

Watanabe, E., Yamato, M., Shiroyanagi, Y., Tanabe, K. & Okano, T. (2011) Bladder augmentation using tissue-engineered autologous oral mucosal epithelial cell sheets grafted on demucosalized gastric flaps. Transplantation, 91(7), 700-706.

Bone marrow stromal cells(骨髄間質細胞)

Pirraco, R. P., Obokata, H., Iwata, T., Marques, A. P., Tsuneda, S., Yamato, M., Reis, R. L. & Okano, T. (2011) Development of osteogenic cell sheets for bone tissue engineering applications. Tissue Eng Part A, 17(11-12), 1507-1515.

Osteoblasts(骨芽細胞)

Uchiyama, H., Yamato, M., Sasaki, R., Sekine, H., Yang, J., Ogiuchi, H., Ando, T. & Okano, T. (2011) In vivo 3d analysis with micro-computed tomography of rat calvaria bone regeneration using periosteal cell sheets fabricated on temperature-responsive culture dishes. J Tissue Eng Regen Med, 5(6), 483-490.

Corneal endothelial cells(角膜内皮細胞)

Lai, J. Y. & Li, Y. T. (2010) Functional assessment of cross-linked porous gelatin hydrogels for bioengineered cell sheet carriers. Biomacromolecules, 11(5), 1387-1397.

Embryonic stem cells(胚性幹細胞)

Matsuura, K., Masuda, S., Haraguchi, Y., Yasuda, N., Shimizu, T., Hagiwara, N., Zandstra, P. W. & Okano, T. (2011) Creation of mouse embryonic stem cell-derived cardiac cell sheets. Biomaterials, 32(30), 7355-7362.
Bel, A., Planat-Bernard, V., Saito, A., Bonnevie, L., Bellamy, V., Sabbah, L., Bellabas, L., Brinon, B., Vanneaux, V., Pradeau, P., Peyrard, S., Larghero, J., Pouly, J., Binder, P., Garcia, S., Shimizu, T., Sawa, Y., Okano, T., Bruneval, P., Desnos, M., Hagege, A. A., Casteilla, L., Puceat, M. & Menasche, P. (2010) Composite cell sheets: A further step toward safe and effective myocardial regeneration by cardiac progenitors derived from embryonic stem cells. Circulation, 122(11 Suppl), S118-123.

Fibroblast (NIH/3T3)(線維芽細胞)

Lee, E. L. & Von Recum, H. A. (2010) Cell culture platform with mechanical conditioning and nondamaging cellular detachment. J Biomed Mater Res A, 93(2), 411-418.

Human 293 (CD4 expressing) cells

Long, Y., Meng, F., Kondo, N., Iwamoto, A. & Matsuda, Z. (2011) Conserved arginine residue in the membrane-spanning domain of hiv-1 gp41 is required for efficient membrane fusion. Protein Cell, 2(5), 369-376.
Kondo, N., Miyauchi, K., Meng, F., Iwamoto, A. & Matsuda, Z. (2010) Conformational changes of the hiv-1 envelope protein during membrane fusion are inhibited by the replacement of its membrane-spanning domain. J Biol Chem, 285(19), 14681-14688.

Macrophages(マクロファージ)

Kato, C. & Kojima, N. (2010) Signr1 ligation on murine peritoneal macrophages induces il-12 production through nfkappab activation. Glycoconj J, 27(5), 525-531.

Peripheral blood mononuclear cells(末梢血単核細胞)

Burt, T. D., Seu, L., Mold, J. E., Kappas, A. & Mccune, J. M. (2010) Naive human t cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin. J Immunol, 185(9), 5279-5288.

Review

Dutta, R. C. & Dutta, A. K. (2010) Comprehension of ecm-cell dynamics: A prerequisite for tissue regeneration. Biotechnol Adv, 28(6), 764-769.
Elloumi-Hannachi, I., Yamato, M., and Okano, T. (2010) Cell sheet engineering: a unique nanotechonology for scaffold-free Tissue reconstruction with clinical applications in regenerative medicine. J lnten Med 267 (1),54-70.
Itoga, K. & Okano, T. (2010) The high functionalization of temperature-responsive culture dishes for establishing advanced cell sheet engineering. J Mater Chem, 20(40), 8768-8775.
Yang, J., Yamato, M., Shimizu, T., Sekine, H., Ohashi, K., Kanzaki, M., Ohki, T., Nishida, K., and Okano, T. (2007). Reconstruction of functional tissues with cell sheet engineering. Biomaterials 28, 5033-5043.
Yang, J., Yamato, M., Nishida, K., Ohki, T., Kanzaki, M., Sekine, H., Shimizu, T., and Okano, T. (2006). Cell delivery in regenerative medicine: the cell sheet engineering approach. Journal of controlled release 116, 193-203.
Yang, J., Yamato, M., Nishida, K., Hayashida, Y., Shimizu, T., Kikuchi, A., Tano, Y., and Okano, T. (2006). Corneal epithelial stem cell delivery using cell sheet engineering: not lost in transplantation. Journal of drug targeting 14, 471-482.

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