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Niwa, H., Yamamura, K.-I. and Miyazaki, J.-I. Efficient selection for high-expression transfectants with a novel eukaryotic vector, Gene, 108, 193-200, 1991. Miyamoto, I., Miura, N., Niwa, H., Miyazaki, J.-I., and Tanaka, K. Mutational analysis of the structure and function of the Xeroderma Pigmentosum group A complementing protein, J. Biol. Chem., 267, 12182-12187, 1992. Niwa, H., Araki, K., Kimura, S., Taniguchi, S.-I., Wakasugi, S. and Yamamura, K.-I. An efficient gene-trap method using poly A trap vectors and characterization of gene-trap events, J. Biochem., 113, 343-349, 1993. Yamashita, S.-I., Ogawa, M., Abe, T., Yamashita, J.-I., Sakamoto, K., Niwa, H. and Yamamura, K.-I. Group II phospholipase A2 in invasive gastric cancer cell line is induced by interleukin 6, Biochem. Biophys. Res. Com., 198, 878-884, 1994. Kimura, S., Niwa, H., Moriyama, M., Araki, K., Abe, K. and Yamamura, K.-I. Improvement of germ line transmission by targeting of b-galactosidase to nuclei in transgenic mice, Develop. Growth & Differ., 36, 521-527, 1994. Niwa, H., Abe, K., Kunisada, T. and Yamamura, K.-I.: Cell-cycle-dependent expression of STK-1 gene encoding a novel murine putative protein kinase, Gene. 169, 197-201, 1996. Abe, K., Niwa, H., Iwase, K., Takiguchi, M., Mori, M., Abe, S.-I., Abe, K. and Yamamura, K.-I. Endoderm-specific gene expression in embryonic stem cells differentiated to embryoid bodies, Exp. Cell Res. 229, 27-34, 1996. Niwa, H., Burdon, T., Chambers, I. and Smith, A. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3, Genes & Dev., 12, 2048-2060, 1998. Nichols, J., Zevnik, B., Anastassiadis, K., Niwa, H., Klewe-Nebenius, D., Chambers, I., Sh?ler, H. and Smith, A. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct-4, Cell, 95,379-391,1998. Hotta, M., Tashiro, F., Ikegami, H., Niwa, H., Ogihara, T., Yodoi, J. and Miyazaki, J.-I. Pancreatic b cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes, J. Exp. Med., 188, 1445-1451, 1998. Tashiro, F., Niwa, H. and Miyazaki, J.-I. Constructing adenoviral vectors by using the circular form of the adenoviral genome cloned in a cosmid and the Cre-loxP recombination system, Human Gene Therapy, 10, 1845-1852, 1999. Burdon, T., Chambers, I., Niwa, H., Stracey, C. and Smith, A. G. Signalling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells, Cells Tissues Organs, 165, 131-143, 1999. Hotz Vitaterna, M., Selby, C. P., Todo, T., Niwa, H., Thompson, C., Fruechte, E. M., Hitomi, K., Thresher, R. J., Ishikawa, T., Miyazaki, J.-I., Takahashi, J. S. and Sancar, A. Differential regulation of mammalian Period genes and circadian rhythmicity by cryptochromes 1 and 2, Proc. Natl. Acad. Sci. USA, 96, 12114-12119, 1999. Miyawaki, K., Yamada, Y., Yano, H., Niwa, H., Ban, N., Ihara, Y., Kubota, A., Fujimoto, S., Kajikawa, M., Kuroe, A., Tsuda, K., Hashimoto, H., Yamashita, T., Jomori, T., Tashiro, F., Miyazaki, J.-I. and Seino, Y. Glucose intolerance caused by a defect in the entero-insular axis: A study in gastric inhibitory polypeptide receptor knockout mice, Proc. Natl. Acad. Sci. USA, 96, 14843-14847, 1999. Niwa, H., Miyazaki, J.-I. and Smith, A. G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells, Nat. Genet., 24, 372-376, 2000. (news & views, Stewart, C.L. : Oct-4, Scene 1: the drama of mouse development, Nat. Genet., 24, 328-330, 2000.) Kawamoto, S., Niwa, H., Tashiro, F., Sano, S., Kondoh, G., Takeda, J., Tabayashi, K. and Miyazaki, J.-I. A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre-mediated recombination, FEBS Letters, 470, 263-268, 2000. Sato, H., Kajikawa, S., Kuroda, S., Horisawa, Y., Nakamura, N., Kaga, N., Kakinuma, C., Kato, K., Morishita, H., Niwa, H. and J.-I. Miyazaki. Impaired fertility in female mice lacking urinary trypsin inhibitor, Biochem. Biophys. Res. Commun., 281, 1154-1160, 2001. Higaki, K., Ninomiya, H., Sugimoto, Y., Suzuki, T., Taniguchi, M., Niwa, H., Pentchev, P. G., Vanier, M. T. and Ohno, K. Isolation of NPC1-deficient chinese hamster ovary cell mutants by gene trap mutagenesis, J. Biochem., 129, 875-880, 2001. Niwa, H. Molecular mechanism to maintain stem cell renewal of ES cells, Cell Struct. Funct., 26, 137-148, 2001. Yamane, T., Kunisada, T., Tsukamoto, H., Yamazaki, H., Niwa, H., Takada, S., Hayashi, S.-I. Wnt signaling regulateshemopoiesis through stromal cells, J. Immunol., 167, 765-772, 2001. Hashimoto, H., Shintani, N., Tanaka, K., Mori, W., Hirose, M., Matsuda, T., Sakaue, M., Miyazaki, J., Niwa, H., Tashiro, F., Yamamoto, K., Koga, K., Tomimoto, S., Kunugi, A., Suetake, S. and Baba, A. Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). Proc Natl Acad Sci U S A., 98, 13355-13360, 2001. |
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丹羽仁史、山村研一 ジーンターゲテイングー最近の進歩、Annual Review 細胞生物学, 308-319, 1992. 丹羽仁史、山村研一 ジーントラップの発生研究への適用、実験医学（増刊）, 10, 174-181, 1992. 丹羽仁史、山村研一 マウス胚幹細胞を用いたジーントラップ、実験医学（増刊）,12, 42-51, 1994. 丹羽仁史 幹細胞とは何かーＥＳ細胞を用いたアプローチー、 細胞工学、16, 1744-1751, 1997. 丹羽仁史 多分化能の維持に働く分子機構、生体の科学、49, 221-226, 1998. 丹羽仁史、宮崎純一 ES細胞を用いた移植治療の展望、バイオインダストリー、17, 42-50, 2000. （再録 ２１世紀の再生医療：監修 井上 一知、pp38-46、シーエムシー、2000） 丹羽仁史 ES細胞の未分化状態を維持する機構、細胞工学、19、384-391、2000. 丹羽仁史 Oct-3/4は発現レベルに応じてES細胞の３通りの分化運命を決定する、実験医学、18, 1511-1514, 2000. 丹羽仁史 ES細胞の分化運命決定機構、蛋白質核酸酵素（増刊：再生医学と生命科学）、45, 2047-2055, 2000. 丹羽仁史 幹細胞とは何か、現代化学、356, 22-26, 2000. 丹羽仁史 ES細胞の移植治療への応用、遺伝子医学、4, 641-646, 2000. 宮崎純一、丹羽仁史、倭英司 ES細胞を用いた再生医学-糖尿病治療への展望-、 Diabetes Frontier、11, 791-800, 2000. 宮崎純一、丹羽仁史 ES細胞からの細胞療法、医学のあゆみ、195, 855-857, 2000. 丹羽仁史 ES細胞の自己複製機構、実験医学（増刊）「幹細胞研究の最前線と再生医療への応用」、19, 23-29, 2001. 丹羽仁史 胚性幹細胞における多能性維持と分化制御の分子メカニズム、医学のあゆみ、199, 945-950, 2001. 升井伸治、丹羽仁史 胚性幹細胞の未分化性維持機構、ゲノム医学、1, 83-91, 2001. 松井久典、丹羽仁史 ES細胞の多能性を維持する分子機構、細胞工学、20, 952-958, 2001. 宮崎純一、丹羽仁史、倭英司 膵ベータ細胞の再生医学、実験医学、19, 364-369, 2001. 宮崎純一、丹羽仁史 ES細胞の分化系と細胞療法への応用、Biotherapy、15, 111-118, 2001. 宮崎純一、丹羽仁史 ES細胞を用いた移植治療の展望、脳の科学、23, 119-126, 2001. 宮崎純一、丹羽仁史 ES細胞とその肝膵疾患への応用の展望、肝胆膵、42, 157-165, 2001. 宮崎純一、丹羽仁史 ES細胞を用いた移植治療の展望、外科、63, 266-272, 2001 |
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