【デコイ4部作】
デコイ4部作があります。4つとも総説論文ですが、まるっきり同じ文章です。ひとつだけ、ThusをThereforeにかえてあるところが笑えますね。やはり阪大デコイグループからの発表です。
Although cells have the capacity to take up naked DNA, this process is extremely inefficient and results in transient transgene expression. This is no surprise given the number of steps encountered that could potentially limit the efficiency of gene transfer. Thus, a number of viral and nonviral vectors have been developed to improve the efficiency of gene transfer. Viral vectors are replication-defective viral particles that retain the ability to enter target cells and transfer their genetic material into the cell’s genome. Replacing genes required for viral replication with an expression cassette for the therapeutic gene transforms viruses into safe vectors that provide delivery and expression of the transgene within the host cell.
Although cells have the capacity to take up naked DNA, this process is extremely inefficient and results in transient transgene expression. This is no surprise given the number of steps encountered that could potentially limit the efficiency of gene transfer. Thus, a number of viral and nonviral vectors have been developed to improve the efficiency of gene transfer. Viral vectors are replication-defective viral particles that retain the ability to enter target cells and transfer their genetic material into the cell’s genome. Replacing genes required for viral replication with an expression cassette for the therapeutic gene transforms viruses into safe vectors that provide delivery and expression of the transgene within the host cell.
Transcription factor decoy oligonucleotide-based therapeutic strategy for renal disease
Although cells have the capacity to take up naked DNA, this process is extremely inefficient and results in transient transgene expression. This is no surprise given the number of steps encountered that could potentially limit the efficiency of gene transfer. Therefore, a number of viral and nonviral vectors have been developed to improve the efficiency of gene transfer. Viral vectors are replication-defective viral particles that retain the ability to enter target cells and transfer their genetic material into the cell’s genome. Replacing genes required for viral replication with an expression cassette for the therapeutic gene transforms viruses into safe vectors that provide delivery and expression of the transgene within the host cell.
Application of decoy oligodeoxynucleotides-based approach to renal diseases
Although cells have the capacity to take up naked DNA, this process is extremely inefficient and results in transient transgene expression. This is no surprise given the number of steps encountered that could potentially limit the efficiency of gene transfer. Thus, a number of viral and nonviral vectors have been developed to improve the efficiency of gene transfer. Viral vectors are replication-defective viral particles that retain the ability to enter target cells and transfer their genetic material into the cell’s genome. Replacing genes required for viral replication with an expression cassette for the therapeutic gene transforms viruses into safe vectors that provide delivery and expression of the transgene within the host cell.
以上4つとも筆頭著者は同一のひとです。