21 June, 2012
Volume 74, Issue 6
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Volume 74, Issue 6
On the cover: Peripheral neurons respond to nerve injury by activating pathways that promote axon regeneration. This proregenerative program includes alteration of gene transcription in the neuronal cell body. The image shows activation of transcription factor c-Jun (stained for phospho-c-Jun in red) in the nuclei of cultured sensory neurons in dorsal root ganglia (green: tubulin; blue: DAPI) following axotomy. The mechanism by which a local injury induces such cell body responses is poorly understood. Shin et al. (pp. 1015–1022) demonstrate that dual leucine zipper kinase (DLK) promotes retrograde injury signaling from the site of axonal lesion in mammals. Genetic deletion of DLK in mice impairs activation of transcription factors in the cell bodies after injury. DLK is required for injury-induced enhancement of axon regeneration, demonstrating an essential role of DLK in regulating injury-signaling pathways.
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Symposium: Neuromodulatory Mechanisms
October 10-12, 2012, New Orleans, LA, USA
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Neuron congratulates editorial board member Cori Bargmann, winner of the 2012 Kavli Prize in Neuroscience.
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