Finding a non-hormonal remedy for hot flashes, one of the most common and disruptive symptoms of menopause, is the holy grail for women who will try just about anything if there’s even a speck of a chance that it could help reduce their frequency or severity. In recent years, there have been a number of research studies investigating whether antidepressants are effective in reducing hot flashes but it’s been a mixed bag of results.
Last summer, I wrote about a randomized, placebo-controlled study (the gold standard in research) that showed 55 percent of women, given the anti-depressant, Lexapro, saw a significant reduction in the frequency and severity of hot flashes they were experiencing daily, though the women on placebo saw an improvement as well, just not as much.
More recently, a double-blind, placebo controlled clinical trial, with 205 participants, also showed some promise. These women were experiencing at least 28 bouts of hot flashes or night sweats a week. The results of that study, published last month, found that compared to placebo, 10-20 mg of Lexapro for eight weeks improved their quality of life by reducing hot flash “interference” and helping with sleep problems.
But another study involving two trials of 36 women, found that Lexapro didn’t help at all. The difference in results might be explained by the “placebo effect.” In the first two studies described here, the women kept a diary to record their hot flash symptoms, filling out a questionnaire every month. In this last study, participants wore detectors to capture objective measures.
Apparently, our desire for something – anything – to work is so powerful that just wishing for some relief makes you feel better.
Nevertheless, researchers continue to explore the use of antidepressants, such as Paxil, Prozac and Effexor, for hot flashes, and a few studies, using these products at low doses, worked for some women, but not all.
To date, the only solution that has been proven to work for hot flashes is hormone therapy. For women looking for a hormone-free alternative, there isn’t better news on the “natural” front. Herbs such as Black Cohosh, Dong Quai and Red Clover (shown here), can help some women for some period of time, but the results are often as unreliable as anti-depressants.
I’d love to know what, if anything, has worked for you. What have you tried that you gave up on?
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