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発表論文

2010年

  1. Harada Naoaki, Zhao Juan, Kurihara Hiroki, Nakagata Naomi, Okajima Kenji: Stimulation of Fc gammaRI on primary sensory neurons increases the insulin-like growth factor-I production, thereby reducing reperfusion-induced renal injury in mice.J Immunol. 2010 Jul 15;185(2):1303-10.
  2. Arai Masatoku, Uchiba Mitsuhiro, Kohmura Hidefumi, Mizuochi Yuichiro, Harada Naoaki, Okajima Kenji: Metformin, an anti-diabetic agent, suppresses the production of tumor necrosis factor and tissue factor by inhibiting early growth response factor-1 expression in human monocytes in vitro.J Pharmacol Exp Ther. 2010 Jul;334(1):206-13.
  3. Kawai Miho, Harada Naoaki, Takeyama Hiromitsu, Okajima Kenji: Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats.Transl Res. 2010 Jun;155(6):294-304.
  4. Zhao Juan, Harada Naoaki, Kurihara Hiroki, Nakagata Naomi, Okajima Kenji: Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice.J Nutr Biochem 2010 Jun 22.
  5. Harada Naoaki, Zhao Juan, Kurihara Hiroki, Nakagata Naomi, Okajima Kenji: Effects of topical application of alpha-D-glucosylglycerol on dermal levels of insulin-like growth factor-i in mice and on facial skin elasticity in humans.Biosci. Biotech. Biochem. 2010　74(4);759-65.
  6. Zhao Juan, Harada Naoaki, Kurihara Hiroki, Nakagata Naomi, Okajima Kenji: Cilostazol improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampus.Neuropharmacology. 2010 March - April;58(4-5):774-83.
  7. Umemura T, Harada N, Kitamura T, Ishikura H, Okajima K. Limaprost reduces motor disturbances by increasing the production of insulin-like growth factor-I in rats subjected to spinal cord injury Transl Res 2010 (in press).
  8. Harada N, Zhao J, Kurihara N, Nakagata N, Okajima K. Resveratrol improves cognitive function in mice by increasing production of insulin-like growth factor-I in the hippocampus J Nutr Biochem 2010 (in press).

2009年

  1. Harada Naoaki, Shimozawa Nobuhiko, Okajima Kenji: AT(1) receptor blockers increase insulin-like growth factor-I production by stimulating sensory neurons in spontaneously hypertensive rats.Transl Res. 2009 Sep;154(3):142-52.
  2. Harada Naoaki, Narimatsu Noriko, Kurihara Hiroki, Nakagata Naomi, Okajima Kenji: Stimulation of sensory neurons improves cognitive function by promoting the hippocampal production of insulin-like growth factor-I in mice.Transl Res. 2009 Aug;154(2):90-102.
  3. Harada Naoaki, Okajima Kenji: Effects of capsaicin and isoflavone on blood pressure and serum levels of insulin-like growth factor-I in normotensive and hypertensive volunteers with alopecia.Biosci Biotech Biochem. 2009 Jun;73(6):1456-9.
  4. Narimatsu Noriko, Harada Naoaki, Kurihara Hiroki, Nakagata Naomi, Sobue Kazuya, Okajima Kenji: Donepezil improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampus.J Pharmacol Exp Ther. 2009 Jul;330(1):2-12.
  5. Zhao Juan, Harada Naoaki, Sobue Kazuya, Katsuya Hirotada, Okajima Kenji: Insulin-like growth factor-I reduces stress-induced gastric mucosal injury by inhibiting neutrophil activation in mice.Growth Horm IGF Res. 2009 Apr;19(2):136-45.
  6. Mizutani Akio, Okajima Kenji, Murakami Kazunori, Mizutani Sachiko, Kudo Kyosuke, Uchino Tetsuya, Kadoi Yuji, Noguchi Takayuki: Activation of sensory neurons reduces ischemia/reperfusion-induced acute renal injury in rats.Anesthesiology. 2009 Feb;110(2):361-9.

2008年

  1. Okajima Kenji, Harada Naoaki: Promotion of insulin-like growth factor-I production by sensory neuron stimulation; molecular mechanism(s) and therapeutic implications.Curr Med Chem. 2008;15(29):3095-112.
  2. Harada Naoaki,Okajima Kenji: Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats.Shock. 2008 Oct;30(4):379-87.
  3. Harada Naoaki, Okajima Kenji, Narimatsu Noriko, Kurihara Hiroki, Nakagata Naomi: Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans.Growth Horm IGF Res. 2008 Aug;18(4):335-44.
  4. Harada Naoaki, Okajima Kenji, Kurihara Hiroki, Nakagata Naomi: Antithrombin prevents reperfusion-induced hepatic apoptosis by enhancing insulin-like growth factor-I production in mice.Crit Care Med. 2008 Mar;36(3):971-4.
  5. Komura Hidefumi, Uchiba Mitsuhiro, Mizuochi Yuichiro, Arai Masatoku, Harada Naoaki, Katsuya Hirotada, Okajima Kenji: Antithrombin inhibits lipopoly saccharide-induced tumor necrosis factor-alpha production by monocytes in vitro through inhibition of Egr-1 expression.J Thromb Haemost. 2008 Mar;6(3):499-507.
  6. Harada Naoaki, Okajima Kenji: Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats.Growth Horm IGF Res. 2008 Feb;18(1):75-81.
  7. Harada Naoaki, Okajima Kenji: New aspects of anti-inflammatory activities of antithrombin-Molecular mechanism(s) and therapeutic implications-. In: Tanaka K, Davie EW (eds) Recent Advances in Thrombosis and Hemostasis. Springer Japan (Tokyo), 2008, pp.218-230.

2007年

  1. Harada Naoaki, Okajima Kenji, Arai Masatoku, Kurihara Hiroki, Nakagata Naomi: Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia.Growth Horm IGF Res. 2007 Oct;17(5):408-15.
  2. Nakayama Takuya, Harada Naoaki, Asano Miki, Nomura Norikazu, Saito Takayuki, Mishima Akira, Okajima Kenji: Atrial natriuretic peptide reduces ischemia/reperfusion-induced spinal cord injury in rats by enhancing sensory neuron activation.J Pharmacol Exp Ther. 2007 Aug;322(2):582-90.
  3. Harada Naoaki, Okajima Kenji: Effect of topical application of capsaicin and its related compounds on dermal insulin-like growth factor-I levels in mice and on facial skin elasticity in humans.Growth Horm IGF Res. 2007 Apr;17(2):171-6.
  4. Harada Naoaki, Okajima Kenji, Kurihara Hiroki, Nakagata Naomi: Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-1, thereby reducing reperfusion-induced apoptosis in mice.Neuropharmacology. 2007 Apr;52(5):1303-11.
  5. Mizuochi Yuichiro, Okajima Kenji, Harada Naoaki, Molor-Erdene Perenlei, Uchiba, Mitsuhiro, Komura Hidefumi, Tsuda Takako, Katsuya Hirotada: Carvedilol, a nonselective β-blocker, suppresses the production of tumor necrosis factor and tissue factor by inhibiting early growth response factor-1 expression in human monocytes in vitro.Transl Res. 2007 Apr;149(4):223-30.
  6. Harada Naoaki, Okajima Kenji: Inhibition of neutrophil activation by lafutidine, an H2-receptor antagonist, through enhancement of sensory neuron activation contributes to the reduction of stress-induced gastric mucosal injury in rats.Dig Dis Sci. 2007 Feb;52(2):469-77.
  7. Kitamura Taisuke, Harada Naoaki, Goto Eiichi, Tanaka Keiichi, Arai Masatoku, Shimada Shoichi, Okajima Kenji: Activation of sensory neurons contributes to reduce spinal cord injury in rats.Neuropharmacology. 2007 Feb;52(2):506-14.
  8. Shimozawa Nobuhiko, Okajima Kenji, Harada Naoaki: Estrogen and isoflavone attenuate stress-induced gastric mucosal injury by inhibiting decreases in gastric tissue levels of CGRP in ovariectomized rats.Am J Physiol Gastrointest Liver Physiol. 2007 Feb;292(2):G615-9.
  9. Harada Naoaki, Okajima Kenji, Kohmura Hidefumi, Uchiba Mitsuhiro, Tomita Tsutomu: Danaparoid sodium reduces ischemia/reperfusion-induced liver injury in rats by attenuating inflammatory responses.Thromb Haemost. 2007 Jan;97(1):81-7.

2006年

  1. Okajima Kenji, Harada Naoaki, Sakurai George, Soga Yukihiro, Suga Hiroyasu, Terada Takahiro, Takao Nakagawa: Rapid assay for plasma soluble E-selectin predicts the development of acute respiratory distress syndrome in patients with systemic inflammatory response syndrome.Transl Res. 2006 Dec;148(6):295-300.
  2. Harada Naoaki, Taoka Yuji, Okajima Kenji: Role of prostacyclin in the development of compression trauma-induced spinal cord injury in rats.J Neurotrauma. 2006 Dec;23(12):1739-49.
  3. Shimozawa Nobuhiko, Okajima Kenji, Harada Naoaki, Arai Masatoku, Ishida Yusuke, Shimada Shoichi, Kurihara Hiroki, Nakagata Naomi: Contribution of sensory neurons to gender difference in the development of stress-induced gastric mucosal injury in mice.Gastroenterolog. 2006 Dec;131(6):1826-34.
  4. Okajima Kenji, Harada Naoaki: Regulation of inflammatory responses by sensory neurons; molecular mechanism(s) and possible therapeutic applications.Curr Med Chem. 2006;13(19):2241-51.
  5. Harada Naoaki, Okajima Kenji, Uchiba Mitsuhiro: Dalteparin, a low molecular weight heparin attenuates inflammatory responses and reduces ischemia-reperfusion-induced liver injury in rats.Crit Care Med. 2006 Jul;34(7):1883-91.
  6. Harada Naoaki, Okajima Kenji, Isobe Hirotaka, Uchiba Mitsuhiro: Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats.Thromb Haemost. 2006 Jun;95(6):1011-8.
  7. Harada Naoaki, Okajima Kenji, Uchiba Mitsuhiro, Kurihara Hiroki, Nakagata Naomi: Antithrombin reduces reperfusion-induced liver injury in mice by enhancing sensory neuron activation.Thromb Haemost. 2006 May;95(5):788-95.
  8. Kurata Masanao, Okajima Kenji, Kawamoto Toru, Uchiba Mitsuhiro, Ohkochi Nobuhiro: Antithrombin reduces reperfusion-induced hepatic metastasis of colon cancer cells.World J Gastroenterol. 2006 Jan 7;12(1):60-5.
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