松田 幹
略歴
1978.03 名古屋大学農学部 食品工業化学科 卒業
1980.03 名古屋大学大学院農学研究科 修士課程 修了
1981.05 名古屋大学大学院農学研究科 博士課程 中途退学
1981.06 名古屋大学 農学部助手
1984.07 農学博士（名古屋大学）
1986.10 コロンビア大学 医学部客員研究員（-1988.08）
1990.02 医学博士（名古屋大学）
1991.01 名古屋大学 農学部 助教授
1995.06 名古屋大学 農学部 教授
1998.04 名古屋大学 大学院生命農学研究科 教授
電子メールアドレス
tmatsuda＠agr.nagoya-u.ac.jp
電話
052-789-4129
FAX
052-789-4128
所属
名古屋大学 大学院生命農学研究科 応用分子生命科学専攻 応用生命化学講座 分子生体制御学研究分野
研究内容
応用生物科学、応用分子細胞生物学、食品科学
様々な生命現象の中でも、特に機能的・形態的変化の大きな現象に興味があり、そこで働くタンパク質や複合糖質などの構造と機能、さらにそれらの発現制御機構の解析を通して、細胞や器官のレベルでの生体制御機構の理解を目指した研究を行っています。現在は、（１）乳腺（細胞）によるタンパク質、脂質、糖質などの合成と分泌に関する研究、（２）鳥類の卵細胞外マトリクスの形成機構と受精・初期発生における機能に関する研究、（３）消化管からのタンパク質や多糖抗原の取り込みと免疫系による認識と応答に関する研究、（４）乳に含まれる腸管ウイルス感染抑制タンパク質に関する研究、などが中心です。
主要な発表論文
<原著論文>
1. Nakatani H, Aoki N, Nakagawa Y, Jin-No S, Aoyama K, Oshima K, Ohira S, Sato C, Nadano D, Matsuda T. Weaning-induced expression of a milk-fat globule protein, MFG-E8, in mouse mammary glands, as demonstrated by the analyses of its mRNA, protein and phosphatidylserine-binding activity. Biochem J., 395, 21-30 (2006)
2. Tanabe, H., Sugiyama, K., Matsuda, T., Kiriyama, S. and Morita T. Small intestinal mucines are secreted in proportion to the setting volume in water of dietary indigestible components in rats. J. Nutr., 135, 2431-2437 (2006)
3. Kozai, H., Yano, H., Matsuda, T., Kato. Y. Wheat-dependent exercise-induced anaphylaxis in mice is caused by gliadin and glutenin treatments. Immunol. Lett., 102(1), 83-90 (2006)
4. Matsuda, T., Matsubara, T. and Hino, S. “Immunogenic and Allergenic Potentials of Natural and Recombinant Innocuous Proteins -Review- J. Biosci. Bioeng., 101(3), 203-211 (2006)
5.
Yamada, C., Izumi H., Hirano,
J., Mizuguchi, A., Kise,
M., Matsuda, T. and Kato, Y.
Degradation of soluble proteins including some allergens in brown rice grains
by endogenous proteolytic activity during germination
and heat-processing. Biosci. Biotech. Biochem. 69(10), 1877-1883 (2005)
6. Ito, M., Kato, T., and Matsuda T. Rice Allergenic proteins, 14-16 kDa albumin and alfa-globulin, remain insoluble in rice grains recovered from rice miso (rice-containing fermented soybean paste) Biosci. Biotech. Biochem. 69(6), 1137-1144 (2005)
7. Okumura H, Kohno Y, Iwata Y, Mori H, Aoki N, Sato C, Kitajima K, Nadano D, and Matsuda T. A newly identified ZP glycoprotein, ZPD, and dimeric ZP1 of chicken egg-envelope are involved in sperm activation on sperm-egg interaction. Biochem. J. 384, 191-199 (2004)
8. Saito, S., Sato, T., Harada, H., and Matsuda, T. Bio-transformation of soy isoflavone-glycosides in laying hens: intestinal absorption and preferential accumulation into egg yolk of equol, a more estrogenic metabolite of daizein. Biochim. Biophys. Acta 1674, 122-130 (2004)
9. Maehashi E, Sato C, Ohta K, Harada Y, Matsuda T, Hirohashi N, Lennarz WJ, Kitajima K. Identification of the sea urchin 350-kDa sperm-binding protein as a new sialic acid-binding lectin that belongs to the heat shock protein 110 family: implication of its binding to gangliosides in sperm lipid rafts in fertilization. J. Biol. Chem. 278, 42050-42057 (2003)
10. Yabe, U., Sato, C, Matsuda, T., and Kitajima, K.: Polysialic acid in human milk - CD36 is a new member of mammalian polysialic acid-containing glycoprotein. J. Biol. Chem., 278, 13875-13880 (2003)
11. Tada, Y., Akagi, H., Fujimura, T., and Matsuda, T.: Effect on an antisense sequence on rice allergen genes comprising a multigene family. Breeding Sci. 53, 61-67 (2003)
12. Sato, C., Matsuda, T., and Kitajima, K.: Neural Differentiation-dependent expression of the disialic acid epitope on CD166 and its involvement in neurite formation in Neuro2A cells. J. Biol. Chem., 277, 45299-45305 (2002)
13. Nadano, D., Notsu, T., Matsuda, T. and Sato, T.-A.: A human gene encoding a protein homologous to ribosomal protein L39 is normally expressed in the testis and derepressed in multiple cancer cells. Biochim. Biophys. Acta 1577, 430-436 (2002)
14. Yano, H., Kato, Y., and Matsuda, T.: Acute excircise induced gastroinduced leakage of allergen in lysozyme-sensitized mice. Eur. J. Appl. Physiol. 87, 358-364 (2002)
15. Nadano, D., Nakayama, J., Matsuzawa, S., Sato, T-A., Matsuda, T., Fukuda, M.N.: Human tastin, a proline-rich cytoplasmic potein, associates with the microtubular cytoskeleton. Biochem J., 364, 669-677 (2002)
16. Fujii, T., Ahn, J.-Y., Kuse, M., Mori, H., Matsuda, T., and Isobe, M.: A novel photoprotein from oceanic squid (Symplectoteuthis oualaniensis) with sequence similarity to mammalian carbon-nitrogen hydrolase domains. Biochem. Biophys. Res. Commun. 293, 874-879 (2002)
17. Kondo, Y., Tokuda, R., Urisu, A., and Matsuda, T.: Cross-reactivity between Japanese cedar pollen and tomato fruit extracts demonstrated using RAST-inhibition and immunoblot inhibition. Clin. Exp. Allergy 32(4), 590-594 (2002)
18. Oshima K, Aoki N, Kato T, Kitajima K, and Matsuda T.: Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles. A possible role in membrane secretion. Eur J Biochem. 269 (4), 1209-1218 (2002)
19. Nakamura, M., Oba, Y., Mori, T., Sato, K., Ishida, Y., Matsuda, T., and Nakamura, H.: Generation of polyclonal antibody against m-Conotoxin GIIIA using an immunogen of [Cys5]m-Conotoxin GIIIA site-specifically conjugated with bovine serum albumin. Biochem. Biophys. Res. Commun. 290, 1037-1041 (2002)
2006年5月1現在