1 to 10 of 35 literature results

• Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.

  Blockade of mineralocorticoid receptor has been shown to improve the clinical outcomes of proteinuric kidney diseases. However, little is known about …

  Authors: Shigeru Shibata, Miki Nagase, Shigetaka Yoshida, Wakako Kawarazaki, Hidetake Kurihara, Hirotoshi Tanaka, Jun Miyoshi, Yoshimi Takai, Toshiro Fujita

  Source: Nature medicine. 2008 Dec

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• Role of Afadin in Vascular Endothelial Growth Factor- and Sphingosine 1-Phosphate-Induced Angiogenesis.

  Rationale: Angiogenesis contributes to physiological and pathological conditions, including atherosclerosis. The Rap1 small G protein regulates vascul…

  Authors: Hideto Tawa, Yoshiyuki Rikitake, Motonori Takahashi, Hisayuki Amano, Muneaki Miyata, Seimi Satomi-Kobayashi, Mitsuo Kinugasa, Yuichi Nagamatsu, Takashi Majima, Hisakazu Ogita,…

  Source: Circulation research. 2010 Apr 22

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• Dual role of DENN/MADD (Rab3GEP) in neurotransmission and neuroprotection.

  DENN/MADD is a component of a signalling protein complex that is localized to the cytosol and exerts multiple functions by using different binding par…

  Authors: Jun Miyoshi, Yoshimi Takai

  Source: Trends in molecular medicine. 2004 Oct

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• RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungs.

  Rho family GTPases have been implicated in the regulation of endothelial permeability via their actions on actin cytoskeletal organization and integri…

  Authors: Matvey Gorovoy, Radu Neamu, Jiaxin Niu, Stephen Vogel, Dan Predescu, Jun Miyoshi, Yoshimi Takai, Vidisha Kini, Dolly Mehta, Asrar B Malik,…

  Source: Circulation research. 2007 Jul 6

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• Molecular perspective on tight-junction assembly and epithelial polarity.

  Apical-basal polarity and a highly organized actin cytoskeleton are main characteristics of epithelial cells that support exchange of ions and nutrien…

  Authors: Jun Miyoshi, Yoshimi Takai

  Source: Advanced drug delivery reviews. 2005 Apr 25

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• Dynamic regulation of p53 subnuclear localization and senescence by MORC3.

  The tumor suppressor p53 is a key transcriptional factor regulating the induction of cellular senescence by oncogenic signals. The activity of p53 is …

  Authors: Keiko Takahashi, Naofumi Yoshida, Naoko Murakami, Kiyo Kawata, Hiroyuki Ishizaki, Miki Tanaka-Okamoto, Jun Miyoshi, Andrew R Zinn, Hiroaki Shime, Norimitsu Inoue

  Source: Molecular biology of the cell. 2007 May

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• Deficiency of nectin-2 leads to cardiac fibrosis and dysfunction under chronic pressure overload.

  The intercalated disc, a cell-cell contact site between neighboring cardiac myocytes, plays an important role in maintaining the homeostasis of the he…

  Authors: Seimi Satomi-Kobayashi, Tomomi Ueyama, Steffen Mueller, Ryuji Toh, Tomoya Masano, Tsuyoshi Sakoda, Yoshiyuki Rikitake, Jun Miyoshi, Hiroaki Matsubara, Hidemasa Oh,…

  Source: Hypertension. 2009 Oct

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• Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites.

  Synaptic scaffolding molecule (S-SCAM) interacts with a wide variety of molecules at excitatory and inhibitory synapses. It comprises three alternativ…

  Authors: Junko Iida, Hiroyoshi Ishizaki, Miki Okamoto-Tanaka, Akira Kawata, Kazutaka Sumita, Shintaro Ohgake, Yuji Sato, Hiroshi Yorifuji, Nobuyuki Nukina, Kazumasa Ohashi,…

  Source: Molecular and cellular biology. 2007 Jun

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• Involvement of afadin in the formation and remodeling of synapses in the hippocampus.

  In the hippocampus, synapses are formed between mossy fiber terminals and CA3 pyramidal cell dendrites and comprise highly developed synaptic junction…

  Authors: Takashi Majima, Hisakazu Ogita, Tomohiro Yamada, Hisayuki Amano, Hideru Togashi, Toshiaki Sakisaka, Miki Tanaka-Okamoto, Hiroyoshi Ishizaki, Jun Miyoshi, Yoshimi Takai

  Source: Biochemical and biophysical research communications. 2009 Aug 7

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• Analysis on the emerging role of Rab3 GTPase-activating protein in Warburg Micro and Martsolf syndrome.

  Evidence is accumulating that Rab3A plays a key role in neurotransmitter release and synaptic plasticity. Recently mutations in the catalytic subunit …

  Authors: Ayuko Sakane, Jun Miyoshi, Yoshimi Takai, Takuya Sasaki

  Source: Methods in enzymology. 2008

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