It was a big year for science. The Large Hadron Collider, arguably the largest science experiment ever, cranked into action before falling silent just nine days later. Read our profile of the man behind the machine, and Nature's Newsmaker of the Year, Lyn Evans.
In our review of the year, we look back over the biggest science stories of 2008, from the creation of the first synthetic genome to the exploration of Mars. You can also read our round-up of the hottest research published in Nature and elsewhere this year; learn about the most exciting scientific method of the year; and meet some of 2008's top prizewinners.